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lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation Through the miR-7-5p/Pax6 Axis
Accumulated evidence indicated that long non-coding RNAs (lncRNAs) involves in numerous biological and pathological processes, including age-related...
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Correction to: lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation Through the miR-7-5p/Pax6 Axis
A correction to this paper has been published: https://doi.org/10.1007/s10528-021-10086-3
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Regenerative and restorative medicine for eye disease
Causes of blindness differ across the globe; in higher-income countries, most blindness results from the degeneration of specific classes of cells in...
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Porcine RPE/Choroidal Explant Cultures
The cultivation of retinal pigment epithelium (RPE)-choroid explants gives the opportunity to study the RPE and Bruch’s membrane in its natural...
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Transcriptome Changes in Retinal Pigment Epithelium Post-PNU-282987 Treatment Associated with Adult Retinal Neurogenesis in Mice
PNU-282987, a selective alpha7 nicotinic acetylcholine receptor agonist, has previously been shown to have both neurogenic and broad regenerative...
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Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation
BackgroundThe retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye....
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The peroxisome: an update on mysteries 3.0
Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in cellular lipid metabolism, such as the β-oxidation of fatty...
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Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish ( Danio rerio ), photoreceptor loss reprograms Müller glia to function as...
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Sirtuins in intervertebral disc degeneration: current understanding
BackgroundIntervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to a variety of...
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Comparative transcriptomic and phenotypic analysis of induced pluripotent stem cell hepatocyte-like cells and primary human hepatocytes
Primary human hepatocytes (PHHs) are used extensively for in vitro liver cultures to study hepatic functions. However, limited availability and...
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Stem Cell Technology in Medical Biotechnology
Stem cells are small, unspecialized, and undifferentiated cells with a chromatin conformation that is not characteristic of any particular cell type...
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
BackgroundThe Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer,...
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EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response
PurposeMolecular composition of circulating small extracellular vesicles (EVs) does not merely reflect the cells of origin, but also is enriched in...
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Introduction and Basic Concepts in Stem Cell Research and Therapy: The Facts and the Hype
Stem cells play critical roles in biological processes, such as tissue development and homeostasis; they also present great promise toward promoting...
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Potential therapeutic effects of crocin
Crocin, a natural bioactive compound derived from saffron ( Crocus sativus ) and other Crocus genera, has gained significant attention recently due to...
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New Therapeutic Approaches Against Ocular Diseases
Ophthalmology aims to enable patients with visual disorders to improve their visual acuity through cutting-edge medicine including retinal prosthesis...
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In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations
The retinal pigment epithelium (RPE) interacts closely with photoreceptors to maintain visual function. In degenerative diseases such as Stargardt...
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Molecular-Genetic Features of Pancreatic Neuroendocrine Tumors
AbstractNeuroendocrine tumors (NETs) account for less than 3% of primary neoplasias of the pancreas. Despite success of the classification, the...
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The complement system in glioblastoma multiforme
The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing...
