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QT-Interval Prolongation Associated with Supratherapeutic Guanfacine Concentration: A Case Report
IntroductionGuanfacine, an alpha-2 adrenergic agonist, is used to treat attention deficit hyperactivity disorder (ADHD). Although cardiovascular...
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Antipsychotics and risk of QT prolongation: a pharmacovigilance study
RationaleWhile meta-analyses of clinical trials found that lurasidone and partial dopamine agonists (brexpiprazole and aripiprazole) were the...
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A case with a trend of QT interval prolongation due to the introduction of methadone to a pancreatic cancer patient on levofloxacin
BackgroundAs methadone can prevent the development of opioid resistance, it has application in alleviating cancer-related pain that proves...
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Case report of QT interval prolongation induced by anamorelin in an obese patient with non-small cell lung cancer
BackgroundAnamorelin, a drug to treat cancer cachexia, binds to ghrelin receptors and improves body weight and appetite. In clinical trials in Japan,...
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Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses
Savolitinib is an oral, potent, and highly selective MET-tyrosine kinase inhibitor under investigation in various tumor types. A thorough QT study...
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Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
The challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition,...
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Physiologic Measures in Diabetes: QTc Prolongation
Cardiovascular disease is the leading cause of mortality in diabetes, necessitating biomarkers beyond traditional methods to stratify risk in these...
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Clinical and Genetic Characteristics of Congenital Long QT Syndrome
AbstractLong QT syndrome is a rare ion channel cardiac disorder, the main manifestations of which are prolongation of the QT interval on the ECG and...
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The Short QT Syndrome
The short QT syndrome (SQTS) is characterised by abbreviated QT intervals on the electrocardiogram and by an increased risk of atrial and ventricular...
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Determinants/Predictors of QT Abnormalities in Patients on Psychotropic Medications in a Nigerian Tertiary Hospital
Cardiovascular disease is a major global burden and a leading cause of premature death among patients with severe mental illness. Over time, research...
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Risk assessment tools for QT prolonging pharmacotherapy in older adults: a systematic review
PurposeMany drugs are associated with the risk of QT prolongation and torsades de pointes (TdP), and different risk assessment tools (RATs) are...
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QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with “Known Risk of Torsades de Pointes”
Many drugs carry some risk of QT interval prolongation, which can lead to life-threatening dysrhythmias including Torsades de Pointes (TdP)....
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Physiologic Measures in Diabetes: QTc Prolongation
Cardiovascular disease is the leading cause of mortality in diabetes, necessitating biomarkers beyond traditional methods to stratify risk in these...
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Delayed QT Prolongation: Derivation of a Novel Risk Factor for Adverse Cardiovascular Events from Acute Drug Overdose
IntroductionIn ED patients with acute drug overdose involving prescription medication and/or substances of abuse, severe QTc prolongation (> 500 ms)...
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Evaluation of Tpeak-end interval, Tpeak-end/QT, and Tpeak-end/Qtc ratio during acute migraine attack in the emergency department
IntroductionDuring an acute migraine attack, changes in ventricular repolarisation parameters may occur due to an imbalance in the autonomic nervous...
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A novel HECW2 variant in an infant with congenital long QT syndrome
Pathogenic variants of HECW2 have been reported in cases of neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL; OMIM...
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PK/PD modeling of a clazosentan thorough QT study with hysteresis in concentration-QT and RR-QT
Clazosentan's potential QT liability was investigated in a thorough QT study in which clazosentan was administered intravenously as a continuous...
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Prevalence, Outcomes, and Predictors of Prolonged Corrected QT Interval in Hydroxychloroquine-Naïve Hospitalized COVID-19 Patients
The studies regarding prevalence, outcomes, and predictors of prolonged corrected QT (QTc) among COVID-19 patients not on QTc-prolonging medication...
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A NOS1AP gene variant is associated with a paradoxical increase of the QT-interval shortening effect of digoxin
Digoxin is characterized by a small therapeutic window and a QT-interval shortening effect. Moreover, it has been shown that the genetic variants of...
