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Association between expiratory mouth pressure and abdominal muscle activity in healthy young males
PurposeTo clarify the association between forced expiration and the abdominal muscles by assessing the relationship between expiratory mouth pressure...
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RNA Multiscale Simulations as an Interplay of Electrostatic, Mechanical Properties, and Structures Inside Viruses
RNA is a functionally rich biomolecule with multiple hierarchical structures that emerge from phenomena occurring at different temporal and spatial...
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Review of microwave imaging algorithms for stroke detection
Microwave imaging is one of the rapidly develo** frontier disciplines in the field of modern medical imaging. The development of microwave imaging...
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Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors
BackgroundThe clinical relevance of circulating tumor cell-white blood cell (CTC-WBC) clusters in cancer prognosis is a subject of ongoing debate....
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The helical axis of anatomical joints: calculation methods, literature review, and software implementation
The calculation of the helical axis, a.k.a. screw axis, is a functional technique that was introduced for the characterization of the motion and the...
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In Vitro Comparison of a Closed and Semi-closed Leaflet Design for Adult and Pediatric Transcatheter Heart Valves
Transcatheter heart valve replacements (TVR) are mostly designed in a closed position (c) with leaflets coaptating. However, recent literature...
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Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
BackgroundRedox signaling caused by knockdown (KD) of Glutathione Peroxidase 2 (GPx2) in the PyMT mammary tumour model promotes metastasis via...
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Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation
Plants of the Schisandra genus are commonly used in folk medicinal remedies. Some Schisandra species and their lignans have been reported to improve...
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NGS-Based Tumor-Informed Analysis of Circulating Tumor DNA
Accurate circulating tumor DNA (ctDNA) detection has an immense biomarker potential in all phases of the cancer disease course. Presence of ctDNA in...
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Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing
BackgroundTyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether...
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Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendiline and NPS R-467
Synthetic routes following a sequential MacMillan organocatalytic asymmetric α-fluorination protocol for aldehydes and then reductive amination, have...
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An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue
We provide a brief overview of recent numerical studies of spiral- and scroll-wave dynamics in mathematical models of cardiac tissue. These waves are...
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Maintenance Therapy with Aromatase Inhibitor in epithelial Ovarian Cancer (MATAO): study protocol of a randomized double-blinded placebo-controlled multi-center phase III Trial
BackgroundA high percentage of epithelial ovarian cancers (EOC) express the estrogen receptor (ER), which is an ideal target for endocrine therapy....
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Human ABL1 deficiency syndrome (HADS) is a recognizable syndrome distinct from ABL1-related congenital heart defects and skeletal malformations syndrome
Germline gain of function variants in the oncogene ABL1 cause congenital heart defects and skeletal malformations (CHDSKM) syndrome. Whether a...
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LncRNA NEAT1 antagonizes the inhibition of melanoma proliferation, migration, invasion and EMT by Polyphyllin B
Polyphyllin B (PPB) is a compound with anti-tumor effects. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long-stranded noncoding RNA that...
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A randomized phase II study of full dose gemcitabine versus reduced dose gemcitabine and nab-paclitaxel in vulnerable patients with non-resectable pancreatic cancer (DPCG-01)
BackgroundAccording to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy,...
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Genomic insights into Plasmodium vivax population structure and diversity in central Africa
BackgroundThough Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human...
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Multimodal epigenetic sequencing analysis (MESA) of cell-free DNA for non-invasive colorectal cancer detection
BackgroundDetecting human cancers through cell-free DNA (cfDNA) in blood is a sensitive and non-invasive option. However, capturing multiple forms of...
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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility
Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn’s disease (CD). However, as with all complex diseases,...
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Stereotactic body radiotherapy versus conventional radiotherapy for painful bone metastases: a systematic review and meta-analysis of randomised controlled trials
BackgroundStereotactic body radiotherapy (SBRT) is a promising approach in treating painful bone metastases. However, the superiority of SBRT over...
