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A Nationwide Study of GATA2 Deficiency in Italy Reveals Novel Symptoms and Genotype–phenotype Association
GATA2 deficiency is a rare disorder encompassing a broadly variable phenotype and its clinical picture is continuously evolving. Since it was first...
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Association between smoking and all-cause mortality in Parkinson’s disease
We aimed to investigate the association between smoking status and all-cause mortality of Parkinson’s disease (PD). Among the whole nationwide...
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Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort...
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Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis
BackgroundComputer gaming has recently been suggested to be associated with benefits for cognition, but its impact on incident dementia remains...
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Female breast cancer incidence predisposing risk factors identification using nationwide big data: a matched nested case-control study in Taiwan
BackgroundBreast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast....
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Risk of dementia in primary aldosteronism compared with essential hypertension: a nationwide cohort study
BackgroundAlthough hypertension is a critical risk factor for dementia, the association between primary aldosteronism (PA) and dementia has been...
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Outcomes in patients with chronic lymphocytic leukemia and TP53 aberration who received first-line ibrutinib: a nationwide registry study from the Italian Medicines Agency
In this analysis we describe the effectiveness of first-line ibrutinib in 747 patients with chronic lymphocytic leukemia (CLL) and TP53 aberrations...
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Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study
Background:Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization...
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Diabetes mellitus and risk of breast cancer: a large-scale, prospective, population-based study
BackgroundThe objective of this study was to evaluate associations of diabetes overall, type 1 diabetes (T1D), and type 2 diabetes (T2D) with breast...
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Uplifts and hassles are related to worsening in chronic fatigue syndrome: a prospective study
BackgroundLimited published data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with...
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Investigating the association between cancer and dementia risk: a longitudinal cohort study
BackgroundPrevious studies found that cancer survivors had a reduced risk of dementia compared with the general population. However, these findings...
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The Genomics of Opioid Addiction Longitudinal Study (GOALS): study design for a prospective evaluation of genetic and non-genetic factors for development of and recovery from opioid use disorder
BackgroundThe opioid use disorder and overdose crisis in the United States affects public health as well as social and economic welfare. While...
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Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase...
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A 28-year prospective analysis of serum vitamin E, vitamin E-related genetic variation and risk of prostate cancer
ObjectiveInvestigate the relationship between serum α-tocopherol concentration and long-term risk of prostate cancer, and evaluate the interaction...
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Migraine, chronic kidney disease and kidney function: observational and genetic analyses
Epidemiological studies demonstrate an association between migraine and chronic kidney disease (CKD), while the genetic basis underlying the...
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The role of genetic predisposition in cardiovascular risk after cancer diagnosis: a matched cohort study of the UK Biobank
BackgroundEvidence is scarce regarding the potential modifying role of disease susceptibility on the association between a prior cancer diagnosis and...
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Impact of Genetic Testing on Therapeutic Decision-Making in Childhood-Onset Epilepsies—a Study in a Tertiary Epilepsy Center
We assessed the frequency of pediatric monogenic epilepsies and precision therapies at a tertiary epilepsy center. We analyzed medical records of...
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Associations between proton pump inhibitors and Alzheimer’s disease: a nested case–control study using a Korean nationwide health screening cohort
BackgroundSafety concerns against the use of proton pump inhibitors (PPIs) based on the risk of dementia, especially Alzheimer’s disease (AD), remain...
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Positive association of Parkinson’s disease with ankylosing spondylitis: a nationwide population-based study
BackgroundAnkylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation...
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Association between depression and young-onset dementia in middle-aged women
BackgroundDementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when...
