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c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
BackgroundEndocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge...
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A brief history of the Feulgen reaction
One hundred years ago, Robert Feulgen published a landmark paper in which he described the first method to stain DNA in cells and tissues. Although a...
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Phase I study of LZM005 in patients with HER2-positive metastatic breast cancer
The prognosis of human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer (MBC) remained unsatisfactory currently, more...
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Polymerase Chain Reaction: An Indispensable Molecular Biology Tool of 21st Century
Due to its universal applications, Polymerase Chain Reaction (PCR) became an essential technique in various scientific branches such as microbiology,...
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Tick-Borne Pathogens Screening Using a Multiplex Real-Time Polymerase Chain Reaction-Based Method
PurposeThis study aims to develop and evaluate a cost-effective, user-friendly multiplex quantitative real-time polymerase chain reaction (qPCR)...
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Digoxin Induces Human Astrocyte Reaction In Vitro
Astrocyte reaction is a complex cellular process involving astrocytes in response to various types of CNS injury and a marker of neurotoxicity. It...
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Utility of AMACR immunohistochemical staining in differentiating Arias-Stella reaction from clear cell carcinoma of ovary and endometrium
BackgroundThe Arias-Stella reaction is a hormone-related atypical endometrial change characterized by cytomegaly, nuclear enlargement, and...
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Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in survivors. The pathogenesis...
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Neratinib for HER2-positive breast cancer with an overlooked option
Positive human epidermal growth factor receptor 2 (HER2) expression is associated with an increased risk of metastases especially those to the brain...
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Preparation of surgical meshes using self-regulating technology based on reaction-diffusion processes
AbstractWhile reaction-diffusion processes are utilized in multiple scientific fields, these phenomena have seen limited practical application in the...
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Detection of apoptotic cells based on in situ hybridization chain reaction using specific hairpins
There are an increasing number of experiments to study programmed cell death/apoptosis, one of the characteristics of which is DNA fragmentation. The...
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Pyrotinib-based therapeutic approaches for HER2-positive breast cancer: the time is now
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) is a highly aggressive subtype associated with poor prognosis. The advent...
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Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization
Foreign body reactions induced by macrophages often cause delay or failure of wound healing in the application of tissue engineering scaffolds. This...
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The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism
Drug metabolism is critical to many aspects of drug safety and efficacy. Thus, understanding the various intricacies of drug metabolism helps to...
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Management of Hospital and Home Positive Airway Pressure Machines During Pandemics
Noninvasive ventilation (NIV) has found its intensive use in respiratory medicine, at home, and in hospitals. Besides, NIV was pivotal in managing...
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee...
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Effect of Maillard reaction on the quality of clarified butter, ghee
In Ayurveda, a traditional Indian medicine system, clarified butter is called ghee and is used for food and medicinal purposes. Since butter is...
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Characterization of CYP3A5 Selective Inhibitors for Reaction Phenoty** of Drug Candidates
CYP3A is one of the most important classes of enzymes and is involved in the metabolism of over 70% drugs. While several selective CYP3A4 inhibitors...
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Development and evaluation of specific polymerase chain reaction assays for detecting Theileria equi genotypes
BackgroundTheileria equi causes equine piroplasmosis, an economically significant disease that affects horses and other equids worldwide. Based on...
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Progress of PD-1/PD-L1 inhibitor combination therapy in immune treatment for HER2-positive tumors
BackgroundPatients with HER2-positive cancers often face a poor prognosis, and treatment regimens containing anti-HER2 have become the first-line...