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Weight-Drop Method for Inducing Closed Head Diffuse Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the foremost causes of disability and death globally. Prerequisites for successful therapy of disabilities...
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Endogenous Regeneration of Alveolar Bone by Decellularized Tooth Matrix
The efficiency of bone tissue regeneration by decellularized tooth matrix, demineralized tooth matrix, and commercial xenograft Bio-Oss Spongiosa was...
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Optic disc detection based on fully convolutional network and weighted matrix recovery model
AbstractEye diseases often affect human health. Accurate detection of the optic disc contour is one of the important steps in diagnosing and treating...
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The Matrix Effect on Nonlinear Optical Responses of Disperse Orange 25: Optical Bistability and Z-Scan
The nonlinear behaviours of an azo dye, Disperse Orange 25 (DO25), doped on two polymers (PVP and PMMA), with different weight percentages are...
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The Link Between Matrix Metalloproteinases and Alzheimer’s Disease Pathophysiology
Alzheimer’s disease (AD) is a major contributor to dementia and the most common neurodegenerative disorder. In AD pathophysiology, matrix...
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Genetic effects on the timing of parturition and links to fetal birth weight
The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a...
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Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue
The extracellular matrix of cirrhotic liver tissue is highly crosslinked. Here we show that advanced glycation end-products (AGEs) mediate...
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Heritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs
BackgroundHeritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host...
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PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper
Interest and efforts to use recombinant adeno-associated viruses (AAV) as gene therapy delivery tools to treat disease have grown exponentially....
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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth,...
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MIRSIG position paper: the use of image registration and fusion algorithms in radiotherapy
The report of the American Association of Physicists in Medicine (AAPM) Task Group No. 132 published in 2017 reviewed rigid image registration and...
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Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier
The present study investigates the preparation of amorphous solid dispersions (ASD) for the ent-kaurane diterpenoid siderol (SDR). Initially,...
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Matrix-bound nanovesicle-associated IL-33 supports functional recovery after skeletal muscle injury by initiating a pro-regenerative macrophage phenotypic transition
Injuries to skeletal muscle are among the most common injuries in civilian and military populations, accounting for nearly 60% of extremity injuries....
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Differences in Gut Microbiota Composition and Predicted Metabolic Functions: a Pilot Study of Adolescents with Normal Weight and Obesity
Understanding the principles underlying the stability and sustainability of the gut microbiome of adolescents with normal weight and obesity will...
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Implantation Effect of a Fibrin Matrix Associated with Mesenchymal Wharton’s Jelly Stromal Cells on the Course of an Experimental Spinal Cord Injury
The efficacy of immediate implantation of a fibrin matrix associated with Wharton’s jelly-derived mesenchymal stromal cells (MSC) was investigated in...
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An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model
It has not been considered that nephrons regenerate in adult mammals. We present that an organ-derived extracellular matrix in situ induces nephron...
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Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR
PurposeTo determine associations between immediate and delayed response of serum cartilage oligomeric matrix protein (sCOMP) to loading (i.e., 3000...
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Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight
BackgroundImpaired skeletal muscle growth in utero can result in reduced birth weight and pathogenesis of intrauterine growth restriction. Fetal and...
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Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn
Advances in neonatology have significantly reduced mortality rates due to prematurity. However, complications of prematurity have barely changed in...
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Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention
BackgroundIntervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering...
