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Curcumol Attenuates Portal Hypertension and Collateral Shunting Via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats
Liver cirrhosis can cause disturbances in blood circulation in the liver, resulting in impaired portal blood flow and ultimately increasing portal...
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Evaluation of Laboratory and Sonographic Parameters for Detection of Portal Hypertension in Patients with Common Variable Immunodeficiency
Timely detection of portal hypertension as a manifestation in a subgroup of patients with common variable immunodeficiency (CVID) represents a...
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A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension
ObjectiveClinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular...
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Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice
Background and aimsKinin B1 receptors (B1Rs) are implicated in the pathogenesis of fibrosis. This study examined the anti-fibrotic effects of B1R...
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Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study
BackgroundPortal hypertension (PHT) has been proven to be closely related to the development of hepatocellular carcinoma (HCC). Whether PHT before...
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Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy
Portal vein tumor thrombosis (PVTT), a common complication of advanced hepatocellular carcinoma (HCC), remains the bottleneck of the treatments....
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Polygenic prediction of preeclampsia and gestational hypertension
Preeclampsia and gestational hypertension are common pregnancy complications associated with adverse maternal and child outcomes. Current tools for...
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Lenvatinib with or without stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis: a retrospective study
Background and objectivesPatients with hepatocellular carcinoma (HCC) involving portal vein tumor thrombosis (PVTT) are presently lacking effective...
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Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report
BackgroundMutations in lysyl-tRNA synthetase ( KARS1 ), an enzyme that charges tRNA with the amino acid lysine in both the cytoplasm and mitochondria,...
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Evidence for a relationship between genetic polymorphisms of the L-DOPA transporter LAT2/4F2hc and risk of hypertension in the context of chronic kidney disease
BackgroundChronic kidney disease (CKD) and hypertension are chronic diseases affecting a large portion of the population frequently coexistent and...
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Gene-based association study reveals a distinct female genetic signal in primary hypertension
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79 worldwide. It is a major risk factor for renal, cerebrovascular,...
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Pulmonary Hypertension in Patients with Common Variable Immunodeficiency
PurposeCommon variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH)...
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CD39 in the development and progression of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a devastating progressive disease characterised by pulmonary arterial vasoconstriction and vascular...
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Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH...
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Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study
AimsThis study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma...
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Prevention of post-tips hepatic encephalopathy: The search of the ideal candidate
Transjugular intrahepatic portosystemic shunt (TIPS) has been used since more than 25 years to treat some of the complications of portal...
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Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury
Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between...
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Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease with high pulmonary arterial pressure, pulmonary vasoconstriction, pulmonary vascular remodeling, and...
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Brachytherapy with Iodine-125 seeds for treatment of portal vein-branch tumor thrombus in patients with hepatocellular carcinoma
BackgroundThere is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate...
