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Polyphenol: Development of Polyphenol-Inspired Derivatives Targeting Pathological Factors of AD
Alzheimer’s disease (AD) is the most common type of dementia having a complex pathophysiology with no disease modifying treatments available in...
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Seasonal variation of alkaloids and polyphenol in Ephedra sinica cultivated in Japan and controlling factors
We investigated the seasonal variation of alkaloids (ephedrine and pseudoephedrine), total polyphenol, and sugar contents in Ephedra sinica ...
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Effects of 7-day polyphenol powder supplementation on cycling performance and lung function in an ozone-polluted environment
PurposePolluted environments can adversely affect lung function and exercise performance. Evidence suggests that some nutrient supplements may offset...
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Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes
Puerarin (Pue) is a naturally bioactive compound with many potential functions in regulating blood glucose and lipid metabolism. However, the low...
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The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels
Drinking fresh grapefruit juice is associated with a significant prolongation of the QT segment on the electrocardiogram (ECG) in healthy volunteers....
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Polyphenol-based targeted therapy for oral submucous fibrosis
Oral submucous fibrosis (OSF) is a chronic, progressive, and precancerous condition mainly caused by chewing areca nut. Currently, OSF therapy...
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Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages
Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even...
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Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage
BackgroundRosmarinic acid (RA) has a wide range of beneficial effects on human health. On the other hand, RA has been reported to induce...
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Natural polyphenol self-assembled pH-responsive nanoparticles loaded into reversible hydrogel to inhibit oral bacterial activity
Periodontitis is one of the most prevalent chronic inflammatory diseases and Polyphenols isolated from Turkish gall play a major role in the...
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Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson’s Disease by GLP-1 Secretion
Parkinson’s disease (PD) is a chronic motor disorder, characterized by progressive loss of dopaminergic neurons. Numerous studies suggest that...
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Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes—secondary analysis of a randomized placebo-controlled parallel intervention trial
BackgroundAronia melanocarpa is a berry rich in polyphenols known for health benefits. However, the bioavailability of polyphenols has been...
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Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis
BackgroundAlteration of the gut microbiota may contribute to the development of inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG),...
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Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy
Food allergy is recognized as a global medical problem with increasing prevalence in recent years. Currently, the treatment of food allergy mainly...
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Gut microbial metabolites of dietary polyphenols and their potential role in human health and diseases
Polyphenols contribute as one of the largest groups of compounds among all the phytochemicals. Common sources of dietary polyphenols are vegetables,...
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Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG
Animal and clinical studies have revealed that (–)-epigallocatechin-3- O -gallate (EGCG), one of the major bioactive polyphenols in green tea, showed...
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Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties
In this study, phenol and benzenesulfonamide substituted pyrazoline derivative novel compounds ( 1a–14a ) were synthesized successfully for the first...
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Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers
Single-strand oligonucleotides provide promising potential as new therapeutics towards various diseases. However, the efficient delivery of...
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Polyphenol-Loaded Nanomedicines Against Skin Aging
Aging of the skin is an unavoidable process, and different factors are responsible for this process, and the major contributing factor is ultraviolet...
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67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG
Purpose of ReviewGreen tea is one of the most consumed beverages in the world. Through in vivo models and clinical trials, several studies have shown...
