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Screening Plasma Proteins for the Putative Drug Targets for Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is one of the most common work-related musculoskeletal disorders. The present study sought to identify putative causal...
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Protein-centric omics integration analysis identifies candidate plasma proteins for multiple autoimmune diseases
It remains challenging to translate the findings from genome-wide association studies (GWAS) of autoimmune diseases (AIDs) into interventional...
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Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development
Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the...
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Plasma-based proteomic profiling identifies the distinct regulation of proteins in hyperplasia and endometrial cancer
BackgroundAmong gynaecological malignancies, endometrial cancer (EC) is the most prevalent type of uterine cancer affecting women. This study...
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Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
BackgroundThe TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include...
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Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome
BackgroundThe inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected...
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The plasma exosomes from patients with primary Sjögren’s syndrome contain epithelial cell–derived proteins involved in ferroptosis
AbstractPrimary Sjögren’s syndrome (pSS) is an autoimmune disease represented by exocrine gland epithelial cell lesions. However, the mechanism...
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Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders
Immune dysregulation has been consistently reported in psychiatric disorders, however, the causes and mechanisms underlying immune dysregulation in...
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Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
BackgroundNeuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed...
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Transcriptomics and Proteomics Approach for the Identification of Altered Blood microRNAs and Plasma Proteins in Parkinson’s Disease
Parkinson's disease (PD) is a neurodegenerative disorder caused by the selective destruction of dopaminergic neurons (DA-nergic). Clinically, PD is...
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Alterations of plasma exosomal proteins and motabolies are associated with the progression of castration-resistant prostate cancer
BackgroundCurrent diagnosis tools for prostate cancer (PCa) such as serum PSA detection and prostate biopsy cannot distinguish dormant tumors from...
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Isolation and Identification of Dengue Virus Interactome with Human Plasma Proteins by Affinity Purification-Mass Spectrometry
Viral proteins evolve to benefit the interaction with host proteins during the infection and replication processes. A comprehensive understanding of...
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Ectodomain shedding of proteins important for SARS-CoV-2 pathogenesis in plasma of tobacco cigarette smokers compared to electronic cigarette vapers: a cross-sectional study
The impact of tobacco cigarette (TCIG) smoking and electronic cigarette (ECIG) va** on the risk of development of severe COVID-19 is controversial....
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Presynaptic Cytomatrix Proteins
The Cytomatrix Assembled at the active Zone (CAZ) of a presynaptic terminal displays electron-dense appearance and defines the center of the synaptic...
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Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
BackgroundBlood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and...
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Immunogenicity of Therapeutic Proteins
The use of proteins for medical applications has revolutionized therapies of many diseases/disorders that were often incurable with small-molecule...