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Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
BackgroundAge-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian...
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IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation
During inflammation, Ly6C hi monocytes are rapidly mobilized from the bone marrow (BM) and are recruited into inflamed tissues, where they undergo...
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A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation
Chronic inflammation and oxidative stress play a pivotal role in the pathophysiology of most challenging illnesses, including cancer, Alzheimer’s,...
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Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How...
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Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine
Excessive reactive oxygen species (ROS) production can induce tissue injury involved in a variety of neurodegenerative disorders such as...
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Age-related blunting of the phagocyte arsenal and its art of killing
Phagocytosis is one of the integral parts of the host defense mechanism employed against invading pathogens. Cells which can sense and identify a...
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Allogeneic HSCT for Symptomatic Female X-linked Chronic Granulomatous Disease Carriers
X-linked chronic granulomatous disease (XL-CGD) is an inherited disorder of superoxide production, causing failure to generate the oxidative burst in...
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Inborn Errors of Immunity—the Sri Lankan Experience 2010–2022
PurposeInborn errors of immunity (IEI) are typically monogenic. Data from the Indian subcontinent are relatively scarce. This paper evaluates IEI...
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Allogeneic Hematopoietic Stem Cell Transplantation Activity in Inborn Errors of Immunity in Russian Federation
PurposeAllogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy for many inborn errors of immunity (IEI). The indications...
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Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal...
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Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity
PurposePatients with inborn errors of immunity (IEI) are at increased risk of severe coronavirus disease-2019 (COVID-19). Effective long-term...
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Peripheral T Cell Populations are Differentially Affected in Familial Mediterranean Fever, Chronic Granulomatous Disease, and Gout
Both innate errors of immunity, such as familial Mediterranean fever (FMF) and chronic granulomatous disease (CGD), and the common inflammatory...
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The Fate of Erythrocytes after Cerebral Hemorrhage
After a cerebral hemorrhage (intracerebral, subarachnoid, and intraventricular), extravasated blood contributes to both initial brain injury, via...
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Factors influencing phagocytosis of malaria parasites: the story so far
There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to...
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Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
BackgroundAgeing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed...
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Correction to: Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine
Actually, the same mice brain extracts were used in both figures, and we thought it was more accurate to check whether in the same mice brain...
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Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution—Diving into Microglia/Macrophage Functions and Therapeutic Modality
After ischaemic cerebral vascular injury, efferocytosis—a process known as the efficient clearance of apoptotic cells (ACs) by various phagocytes in...
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Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
AbstractThe underlying mechanisms of asbestos-related autoimmunity are poorly understood. As the size, surface reactivity, and free radical activity...
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Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation
Patients with chronic granulomatous disease (CGD) who have mutated phagocyte NADPH oxidase are susceptible to infections due to reduced reactive...
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Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation
ObjectivePseudomonas aeruginosa effectively facilitate resistance to phagocyte killing by biofilm formation. However, the cross talk between biofilm...
