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SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer
BackgroundThe effect of SPP1 in squamous cell carcinoma of the penis (PSCC) remained unknown. We attempted to clarify the function of the SPP1 gene...
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Increased HRD score in cisplatin resistant penile cancer cells
Background/IntroductionPenile cancer is a rare disease in demand for new therapeutic options. Frequently used combination chemotherapy with 5...
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Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study
BackgroundHPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to...
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Incidence of penile intraepithelial neoplasia and incidence and survival of penile cancer in Denmark, 1997 to 2018
PurposeSquamous cell carcinoma (SCC) of the penis is rare. Some studies have suggested that the incidence is increasing but the available literature...
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A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease
BackgroundAlthough penile cancer (PC) is uncommon in developed countries, it is widespread in develo** countries. The state of Maranhão (Northeast,...
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HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics
BackgroundPenile cancer is one of the most aggressive male tumors. Although it is preventable, the main etiologic causes are lifestyle behaviors and...
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Utility of a penile compression device for the quality of life in male patients with urinary incontinence after prostatectomy (the MORE study): a randomized prospective study
ObjectivesTo verify the effects of penile clam** on the degree of stress urinary incontinence and quality of life in post-radical prostatectomy...
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BIRC5 regulates inflammatory tumor microenvironment-induced aggravation of penile cancer development in vitro and in vivo
BackgroundBaculoviral IAP repeat containing 5 (BIRC5) is overexpressed and plays as a key regulator in the progression of various human carcinomas....
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Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma
PurposeTo compare Cancer-specific mortality (CSM) in patients with Squamous cell carcinoma (SCC) vs. non-SCC penile cancer, since survival outcomes...
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Italian observational study on HPV infection, E6, and p16 expression in men with penile cancer
BackgroundHuman Papillomavirus (HPV) infection is one of the most important causes of cancer. It can play a role in cervical and extra-cervical...
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Inflammation and Cancer
Virchow (1864) observed that tumor stroma is frequently invaded by inflammatory cells and proposed a relationship between inflammation and cancer for...
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The Road to Cervical Cancer Elimination
An estimated 34,800 cancers in the United States were caused by HPV between 2012 and 2016. Among those cancers (cervical, vulvar, vaginal, anal,...
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Geographic variation of HPV-associated cancer incidence in Kentucky using spatial scan statistics
PurposePopulations with high cancer risk that are targeted for screening, education, and vaccination have been shown to increase rates of screening,...
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Tumor Microenvironment in Penile Cancer
Penile cancer is rare but associated with a high morbidity and mortality once metastasized. Besides presenting a fundamental overview of penile...
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Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study
BackgroundThe high-risk human papillomavirus (HPV) infection represents one of the main etiologic pathways of penile carcinogenesis in approximately...
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Cancer Prevention
Cancer prevention can be categorized as primary, secondary, or tertiary. Prevention may address entire populations or individuals and families at...
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A cohort study among 402 patients with penile cancer in Maranhão, Northeast Brazil with the highest worldwide incidence
ObjectiveMaranhão State—Northeast Brazil–has the world’s highest incidence of penile cancer. This study describes the epidemiological,...
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The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
BackgroundUnderstanding relationships between presenting symptoms and subsequently diagnosed cancers can inform symptom awareness campaigns and...
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Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa
BackgroundPenile cancer is a rare malignancy with prevalence higher in areas of high Human Papilloma Virus (HPV) such as Africa, Asia and South...
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Cytotoxic Cancer Drugs
Chemotherapy is one of the pillars of cancer treatment, with first reports of its use dating back hundreds of years. Cytotoxic drugs damage malignant...