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Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria
The breakdown of the gut’s mucosal barrier that prevents the infiltration of microorganisms, inflammatory cytokines and toxins into bodily tissues...
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Pharmacokinetic Parameters of Oral Pegylated IFN-λ1
We studied the pharmacokinetics of a pegylated IFN-λ1 (PEG IFN-λ1) after its oral administration to rats in different therapeutic doses. The...
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Dual Role of Interferon in Cancer Immunity
The use of immunotherapy continues to improve the outcome of cancer patients, including those with advanced diseases. Interferon (IFN) therapy is the...
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Effect of interferon-α on COVID-19 in-hospital mortality: a large-scale propensity score-matched study
BackgroundCoronavirus infection can induce the production of inflammatory cytokines leading to acute respiratory distress syndrome (ARDS) and death....
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The combination of PD-1 blockade with interferon-α has a synergistic effect on hepatocellular carcinoma
BackgroundThe efficacy of immune checkpoint inhibitors (ICIs), such as programmed cell death protein-1 (PD-1) or its ligand 1 (PD-L1) antibody, in...
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Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms
Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into...
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Treatment of Hepatitis E
Hepatitis E virus (HEV) infections are the most common cause of acute hepatitis, but they can also take a chronic course. There is no specific...
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Immunogenicity Risk Assessment for PEGylated Therapeutics
The objective of this manuscript is to provide the reader with two examples on how to present an immunogenicity risk assessment for a PEGylated...
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Pharmacogenetic Predictors of Response to Interferon Beta Therapy in Multiple Sclerosis
First-line therapy with interferon beta (IFN-β), involved in gene expression modulation in immune response, is widely used for multiple sclerosis....
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The Contribution of PEG Molecular Weights in PEGylated Emulsions to the Various Phases in the Accelerated Blood Clearance (ABC) Phenomenon in Rats
PEGylated preparations will be cleared rapidly from blood circulation when they are administrated twice in the same animal at a time interval,...
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Management of Hepatitis C Virus: Current and Future Treatments
Globally, hepatitis C virus (HCV), the most important health issue, is a meticulous factor in liver disease. Its cure is now possible for most people...
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Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function
Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients....
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Effects of interferon-alpha on hippocampal neurogenesis and behavior in common marmosets
In many mammalian species, the production of new neurons in the hippocampal dentate gyrus continues throughout life. Previous studies using rodents...
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Liposome-Mediated Anti-Viral Drug Delivery Across Blood–Brain Barrier: Can Lipid Droplet Target Be Game Changers?
Lipid droplets (LDs) are subcellular organelles secreted from the endoplasmic reticulum (ER) that play a major role in lipid homeostasis. Recent...
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Immunotherapy for Cutaneous Melanoma
Melanoma is the most aggressive skin cancer whose incidence is increasing in western countries. Among novel treatments, immunotherapy has shown...
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Interferons and Interleukins
In this chapter, the complex role of interferons and interleukins in our defense system to defend against, contain, or eliminate toxic or invasive...
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Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B
Current data of hepatitis B virus (HBV) variants associated with treatment outcome identified by next generation sequencing (NGS) are limited. This...
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Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer
BackgroundAdjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with...
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Develo** Engineered Nano-Immunopotentiators for the Stimulation of Dendritic Cells and Inhibition and Prevention of Melanoma
ObjectiveThis study aims to utilize PEGylated poly (lactic-co-glycolic acid) (PLGA) nanoparticles as a delivery system for simultaneous...
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Moving Fast Toward Hepatitis B Virus Elimination
Currently, there are two safe and effective therapeutic strategies for chronic hepatitis B treatment, namely, nucleoside analogs and interferon alpha...