Search
Search Results
-
The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway
Aspartame (ASP) as an important sugar substitute is widely used in pharmaceutical and food processing. Here, we compared the effects of ASP and...
-
In Vivo Bioluminescence for the Detection of the Fate of Pancreatic Islet Organoids Post-transplantation
Pancreatic islet transplantation is a promising cell replacement treatment for patients afflicted with type 1 diabetes (T1D), which is an autoimmune...
-
-
Radioprotective effects of α2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage
Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the...
-
Islet-on-a-chip for the study of pancreatic β-cell function
Diabetes mellitus is a significant public health problem worldwide. It encompasses a group of chronic disorders characterized by hyperglycemia,...
-
Isolation and Purification of Human Pancreatic Islets
Successful islet isolation is the key to islet transplantation in diabetic patients. However, islet isolation is a technically complex and...
-
Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation
Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets in sufficient quantities. Cryopreservation could...
-
In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation
We describe step-by-step methods to label human pancreatic islet cells and murine insulinoma cells and their subsequent transplantation into type I...
-
Endothelial Cells Promote Pseudo-islet Function Through BTC-EGFR-JAK/STAT Signaling Pathways
Interactions between cells are of fundamental importance in affecting cell function. In vivo, endothelial cells and islet cells are close to each...
-
Infection with the enteric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node
In nonobese diabetic (NOD) mice, C. rodentium promotes priming of islet-specific T-cells in pancreatic lymph nodes (PaLN), which is a critical step...
-
Recent progress in pancreatic islet cell therapy
Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in...
-
Morphological alteration of the pancreatic islet in ovariectomized rats fed a high-fat high-fructose diet
Diabetes and its complications are major causes of mortality worldwide. Type 2 diabetes coexists with insulin resistance and β-cell dysfunction,...
-
Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes
Pancreatic islets are the body’s central rheostat that regulates glucose homeostasis through the production of different hormones, including β...
-
Synthesis of siRNA-Conjugated Dextran-Coated Iron Oxide Nanoparticles for Islet Protection During Transplantation and Noninvasive Imaging
Pancreatic islet transplantation (Tx) has a lifesaving potential for type 1 diabetes (T1D) patients. Islet damage during and after transplantation is...
-
Vascularized Islet Transplantation as Composite Islet-Kidney Grafts with Nanoparticle-Labeled Islets in Large Animal Preclinical Transplant Models
Although there are many patients with diabetes and end-stage renal failure (DM/ESRD) who would benefit from a transplantation strategy that addresses...
-
Cancer-Derived Immunoglobulin G and Pancreatic Cancer
Immunoglobulin (Ig) is traditionally believed to be produced solely by B cells. Nonetheless, mounting evidence has demonstrated that various types of...
-
Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes
BackgroundIslet transplantation is a promising minimally invasive approach that dispenses with many challenges, especially immunological...
-
Par-4-Dependent Apoptosis of Pancreatic Islet β Cells in Type 2 Diabetes
Pancreatic islet β-cell dysfunction is an underlying cause of type 2 diabetes. Long-term metabolic disorders lead to pancreatic islet β-cell...
-
LINC-p21 Regulates Pancreatic β-Cell Function in Type 2 Diabetes Mellitus
This study aimed to investigate the underlying mechanism and assess the biological role of long intergenic non-coding RNA (LINCRNA)-p21 in type 2...
-
TFP5, a Peptide Derived from Cdk5 Activator p35, Protects Pancreatic β Cells from Glucose Toxicity
We studied the effect of TFP5 on MIN6 cells (cultured mouse islet β cells) treated with different concentrations of glucose (5 or 25 mM). The results...