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Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
The use of apex vessels may solve coning problems associated with dissolution testing. However, excessive dissolution acceleration can reduce the...
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Potential Application of USP Paddle and Basket Dissolution Methods in Discriminating for Portioned Moist Snuff and Snus Smokeless Tobacco Products
The focus of the study was to develop discriminatory dissolution methods for portioned snus and moist snuff sub-categories of smokeless tobacco...
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Evaluation of microstructure, dissolution rate, and oral bioavailability of paclitaxel poloxamer 188 solid dispersion
Poor solubility is a major challenge for enhancing the oral bioavailability and clinical application of many drugs, including the broad-spectrum...
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Effect of Food Viscosity on Drug Dissolution
PurposeThe purpose of the present study was to investigate the effect of food viscosity on the dissolution rate of a drug. There are two types of...
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Gel Strength of Hydrophilic Matrix Tablets in Terms of
In Vitro RobustnessPurposeThe purpose of this study was to correlate the gel strength of swollen matrix tablets with their in vitro robustness against agitation...
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Combination of co-crystal and nanocrystal techniques to improve the solubility and dissolution rate of poorly soluble drugs
PurposeSolubility and dissolution rate are essential for the oral absorption and bioavailability of poorly soluble drugs. The aim of this study was...
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Dissolution Kinetics of Nifedipine—Ionizable Polymer Amorphous Solid Dispersion: Comparison Between Bicarbonate and Phosphate Buffers
PurposeThe intestinal fluid pH is maintained by the bicarbonate buffer system that shows unique properties regarding drug dissolution. Nevertheless,...
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Single-crystal Drying: Development of a Continuous Drying Prototype to Optimize Particle Flow and Residence Time Distribution
PurposeIn the pharmaceutical industry, there has been a growing interest in continuous manufacturing in recent years. Many efforts have been made to...
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Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion Spheronization Technique for Dissolution Rate Enhancement of Curcumin
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes...
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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration
Background and ObjectiveThere are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased...
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Unmet technological demands in orodispersible films for age-appropriate paediatric drug delivery
Age-appropriateness of a formulation is the ability to deliver variable but accurate doses to the paediatric population in a safe and acceptable...
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Impact of Apparatus and Adapter on In vitro Drug Release of Ophthalmic Semisolid Drug Products
PurposeIn vitro release testing (IVRT) is a widely used tool for evaluating the quality and performance of drug products. However, standardized...
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Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion
(20 S)-Ginsenoside Rh2 is a natural saponin derived from Panax ginseng Meyer (P. ginseng), which showed significantly potent anticancer properties....
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Guar gum as a microbially degradable component for an oral colon delivery system based on a combination strategy: formulation and in vitro evaluation
Oral colon delivery has widely been pursued exploiting naturally occurring polysaccharides degraded by the resident microbiota. However, their...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Solubility vs Dissolution in Physiological Bicarbonate Buffer
BackgroundPhosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although...
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Evaluation of Manufacturer-to-Manufacturer Variability of Croscarmellose Sodium: Influence on the Dissolution of Sitagliptin Tablets (Water-Soluble Drug) and Escitalopram Tablets (Sparingly Soluble Drug)
The present study aimed to investigate if the manufacturer variability of croscarmellose sodium, a superdisintegrant, could have an impact on the...
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Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets
Abuse-deterrent formulations (ADFs) using physical/chemical barrier approaches limit abuse by providing resistance to dosage form manipulation to...
