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Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance
Multidrug resistance (MDR) is a key determinant for hepatocellular carcinoma chemotherapy failure. P-glycoprotein is one of the main causes of MDR by...
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Trastuzumab for Active Targeting in Cancer Therapy
With the advent of targeted therapies came a new paradigm for cancer treatment. The specific interaction between ligands and surface receptors has...
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Boosting antitumor efficacy using docetaxel-loaded nanoplatforms: from cancer therapy to regenerative medicine approaches
The intersection of nanotechnology and pharmacology has revolutionized the delivery and efficacy of chemotherapeutic agents, notably docetaxel, a key...
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Physical and Analytical Techniques Used for the Characterization of Polymeric Micelles
Nanomedicines are notably the intriguing strategies for addressing diverse challenges allied with drug delivery. Polymeric micelles, a self-assembled...
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Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
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Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease
Resveratrol is a natural polyphenol which may be useful for treating neurodegenerative diseases such as multiple sclerosis (MS). To date, current...
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Facile Technology for Extemporaneous Preparation of Long-Acting Injectable Microparticulate Suspensions at the Patient Side
In this study, we present an innovative and facile in situ approach for extemporaneous preparation of sterile microparticles. An amazingly simple...
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Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: In Vitro and In Vivo Evaluation
PurposeIn this study, a new modified nanoprecipitation approach that more efficient and simpler than conventional approach was developed to...
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Epilepsy Treatment and Diagnosis Enhanced by Current Nanomaterial Innovations: A Comprehensive Review
Epilepsy is a complex disease in the brain. Complete control of seizure has always been a challenge in epilepsy treatment. Currently, clinical...
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Advanced Delivery Strategies of Nintedanib for Lung Disorders and Beyond: A Comprehensive Review
Nintedanib, a primary treatment for lung fibrosis, has gathered substantial attention due to its multifaceted potential. A tyrosine kinase inhibitor,...
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A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems
The gastrointestinal mucus barrier is a widely overlooked yet essential component of the intestinal epithelium, responsible for the body’s protection...
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Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug therapy. But presently, detailed investigations have...
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Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review
Breast cancer due to the unpredictable and complex etiopathology combined with the non-availability of any effective drug treatment has become the...
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Inhalable Nanoparticle-based Dry Powder Formulations for Respiratory Diseases: Challenges and Strategies for Translational Research
The emergence of novel respiratory infections (e.g., COVID-19) and expeditious development of nanoparticle-based COVID-19 vaccines have recently...
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Functionalization of Nanosystems in Cancer Treatment
Cancer is the major public health problem worldwide, with high rates of incidence and lethality. The leak of specificity of the treatments currently...
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Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the...
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Development and In Vitro Evaluation of Crizotinib-Loaded Lipid–Polymer Hybrid Nanoparticles Using Box–Behnken Design in Non-small Cell Lung Cancer
The goal of the study was to produce, optimize, characterize, and compare crizotinib-loaded lipid-polymer hybrid nanoparticles (CL-LPHNPs),...
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Theranostic Applications of Functionalized Polymeric Nanoparticles
Nanoparticles offer a potential alternative for drug delivery with a promising targeting efficiency attributed to their size and tailor-made...
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Lipid- and TPGS-Based Core–Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential
The current study elucidates the improved drug loading of paclitaxel (PTX) in lipid- and d -α-tocopheryl polyethylene glycol succinate (TPGS)–based...
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Nanomedicines Obtained by 3D Printing
Nanomedicine encompasses the use of nanotechnology for medical applications. The development of nano-based drug delivery systems has revealed new...