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The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus
Cellular arachidonic acid (AA), an unsaturated fatty acid found ubiquitously in plasma membranes, is metabolized to different prostanoids, such as...
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Fatty Acids and Immunomodulation
Cells require energy as source for survival. One of the major sources of energy is derived from lipids which are obtained from either dietary sources...
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Polypharmacology in Clinical Applications—Anti-inflammation Polypharmacology
Inflammation, a vital defense mechanism for health, is defined as the immune system’s response to harmful stimuli such as pathogens, damaged cells,...
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Screening Methods for the Evaluation of Antianginal Agents
In humans, angina is a multifactorial disease influenced by multiple pathogenic factors having a variable course and outcome in each patient. The...
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Inflammatory Mediators and Intracellular Signalling
Inflammation is a protective response of the macroorganism to injury caused by trauma, noxious chemicals or microbiological toxins. This response is...
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Blood Constituents and Safety Pharmacology: In Vitro and In Vivo Thrombosis and Hemostasis Assays
Thrombosis and related disorders represent the number one cause of mortality. The understanding of the mechanisms behind the pathogenesis of venous...
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Mediators of Inflammation
Inflammation is a physiologic response against noxious stimuli and microbial invaders. The basic elements of inflammation include host cells, blood...
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Pacemaker Mechanisms Driving Pyeloureteric Peristalsis: Modulatory Role of Interstitial Cells
The peristaltic pressure waves in the renal pelvis that propel urine expressed by the kidney into the ureter towards the bladder have long been...
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The Pulmonary Vasculature and Dawes’ Foetal and Neonatal Physiology
During the 1960s, Dawes with Sidney Cassin (1928–2010), Joan Mott, and other colleagues worked to understand the regulation of pulmonary vascular...
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Membrane Lipids and Modulation of Vascular Smooth Muscle Ion Channels
In vascular smooth muscle (VSM), lipids regulate the function of many cellular proteins, including ion channels. Lipids can directly target ion...
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Anti-Inflammatory Activity
Inflammation was characterized 2,000 years ago by Celsus by the four Latin words: rubor, calor, tumor, and dolor. Inflammation has different phases:...
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Eicosanoid storm in infection and inflammation
Controlled immune responses to infection and injury involve complex molecular signalling networks with coordinated and often opposing actions....
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Pharmacological Effects on Gastric Function
Originally Gosh and Schild (1958) introduced a method for the continuous recording of gastric acid secretion in the stomach lumen-perfused...
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Basic and Clinical Aspects of Bradykinin Receptor Antagonists
Bradykinin and related kinins may act on two types of receptors designated as B1 and B2. It seems that the B2 receptors are most commonly found in...
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Anti-inflammatory Activity
Inflammation was characterized 2,000 years ago by Celsus by the four Latin words: rubor, calor, tumor, and dolor. Inflammation has different phases:...
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The Pulmonary Vasculature and Dawes’ Foetal and Neonatal Physiology…
During the 1960s, Dawes with Sidney Cassin (1928–2010), Joan Mott, and other colleagues worked to understand the regulation of pulmonary vascular...
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Oxidoreductase Inhibitors
Chemical reactions that occur via the exchange of electrons are termed redox reactions. Normally the carbon atom changes its oxidation state in...