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LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and...
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Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis
BackgroundIn light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying...
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Local coordination of epithelial planar polarity in the maintenance and regeneration of the adult rat airway
The maintenance of planar polarity in airway multiciliated cells (MCCs) has been poorly characterized. We recently reported that the direction of...
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An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling
Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates...
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PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia
BackgroundPrickle planar cell polarity protein 1 (PRICKLE1), a core component of the non-canonical Wnt/planar cell polarity (PCP) pathway, was...
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Rare copy number variations of planar cell polarity genes are associated with human neural tube defects
Select single-nucleotide variants in planar cell polarity (PCP) genes are associated with increased risk for neural tube defects (NTDs). However,...
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Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects
Extensive studies that have sought causative mutation(s) for neural tube defects (NTDs) have yielded limited positive findings to date. One possible...
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Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus
Heterozygous mutations affecting FOXJ1 , a transcription factor governing multiciliated cell development, have been associated with obstructive...
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WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways
Neural tube defects (NTDs) are debilitating human congenital abnormalities due to failure of neural tube closure. Sonic Hedgehog (SHH) signaling is...
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sFRP1 protects H9c2 cardiac myoblasts from doxorubicin-induced apoptosis by inhibiting the Wnt/PCP-JNK pathway
Doxorubicin (Dox) is an effective chemotherapy drug against a wide range of cancers, including both hematological and solid tumors. However, the...
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Dispensable role of Rac1 and Rac3 after cochlear hair cell specification
AbstractRac small GTPases play important roles during embryonic development of the inner ear; however, little is known regarding their function in...
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Polarity scaffolds signaling in epithelial cell permeability
As an integral part of the innate immune system, the epithelial membrane is exposed to an array of insults that may trigger an immune response. One...
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Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus
AQP4 is expressed in the endfeet membranes of subpial and perivascular astrocytes and in the ependymal cells that line the ventricular system. The...
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Molecular Pathways and Animal Models of Defects in Situs
Left–right patterning is among the least well understood of the three axes defining the body plan, and yet it is no less important, with left–right...
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Wnt Signaling in Cancer
Stringent regulation of the Wnt pathways components and modulators is indispensable for the restoration of tissue homeostasis and development. The...
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Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3...
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Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact
Autism spectrum disorders (ASD) involve brain wide abnormalities that contribute to a constellation of symptoms including behavioral inflexibility,...
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Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants
The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after...
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Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs
The pattern of blood fluid shear stress (FSS) is considered the main factor that affects ciliogenesis in human umbilical vein endothelial cells...
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FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells
The transcription factor FOXO3 is necessary to preserve cochlear hair cells. Growth factors, including TGF-β, closely contribute to cochlear hair...
