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Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases
Osteogenesis imperfecta type 10 (OI10) is caused by loss of function codon variants in the gene SERPINH1 that encodes heat shock protein 47 (HSP47),...
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Rotenone-Induced Model of Parkinson’s Disease: Beyond Mitochondrial Complex I Inhibition
Parkinson’s disease (PD) is usually diagnosed through motor symptoms that make the patient incapable of carrying out daily activities; however,...
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Nutrigenomics in Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world (Ball et al. 2019). PD is characterized by the progressive...
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Platforms for Analyzing Networks of Neurodegenerative and Psychiatric Diseases
Cellular functions are controlled by genetic networks, and possible mutations in genes produce aberrations in normal cellular activity, disrupting...
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The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-aged people and elderly people, and the pathogenesis of PD is...
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Mitophagy Impairments as Culprit of Alzheimer’s Disease
Dementia is considered as a common term which includes different disease known to affect memory and other cognitive abilities too. Amongst different...
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Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at...
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Regulatory Role of ADGRL3, PARK2, and CNTNAP2 in Neurodevelopmental Disorders
Adhesion G protein-coupled receptors (AGPCRs) are a 33-member subfamily of Class B GPCRs that control many physiological processes and are implicated...
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Autophagy genes in biology and disease
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways...
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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype
Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved...
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Genetic Models of Parkinson’s Disease
Parkinson’s disease (PD) is a chronic and evolving neurodegenerative disorder primarily due to the progressive loss of substantia nigra pars compacta...
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Whole-Exome Sequencing Study of Consanguineous Parkinson’s Disease Families and Related Phenotypes: Report of Twelve Novel Variants
Parkinson’s disease (PD) is a common progressive neurodegenerative disorder with motor and nonmotor symptoms. Recent studies demonstrate various...
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Platforms for Analyzing Networks of Neurodegenerative and Psychiatric Diseases
Cellular functions are controlled by genetic networks, and possible mutations in genes produce aberrations in normal cellular activity, disrupting...
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Targeting mitophagy for neurological disorders treatment: advances in drugs and non-drug approaches
Mitochondria serve as a vital energy source for nerve cells. The mitochondrial network also acts as a defense mechanism against external stressors...
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Molecular genetics of Parkinson’s disease: Contributions and global trends
Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by motor dysfunction. Aging is the greatest risk factor for...
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Animal Models Used for Studying the Benefits of Probiotics in Neurodegeneration
Neurodegenerative sicknesses, viz., Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal...
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Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia
Accumulating evidence strongly supports that PINK1 mutation can mediate mitochondrial autophagy dysfunction in dopaminergic neurons. This study was...
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Towards improved screening of toxins for Parkinson’s risk
Parkinson’s disease (PD) is a chronic, progressive and disabling neurodegenerative disorder. The prevalence of PD has risen considerably over the...
