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Purinergic P2X Receptors as Therapeutic Targets

Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three...

Leanne Stokes, Stefan Bidula, Ronald Sluyter in Ion Channels as Targets in Drug Discovery

Chapter 2024

Molecular insights into P2X signalling cascades in acute kidney injury

Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized individuals. The complex pathophysiology...

Swati Mishra, Vishwadeep Shelke, ... Anil Bhanudas Gaikwad in Purinergic Signalling

Article 22 January 2024

Triggering of Major Brain Disorders by Protons and ATP: The Role of ASICs and P2X Receptors

Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells. Less known is that this molecule has a variety of...

Andrii Cherninskyi, Maksim Storozhuk, ... Oleg Krishtal in Neuroscience Bulletin

Article 29 November 2022

Enlightening activation gating in P2X receptors

P2X receptors are trimeric nonselective cation channels gated by ATP. They assemble from seven distinct subunit isoforms as either homo- or...

Christian Sattler, Klaus Benndorf in Purinergic Signalling

Article Open access 21 February 2022

Purinergic P2X₃ receptors in the carotid body as new therapeutic targets for controlling heart failure

Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced...

**meng He, Zhichao Zhou in Purinergic Signalling

Article Open access 22 May 2023

Electroacupuncture regulates the P2X₇R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye

Dry eye (DE) is a prevalent ocular surface disease in patients with type 2 diabetes (T2DM). However, current medications are ineffective against...

Mi-Mi Wan, Zhang-Yitian Fu, ... Wei-** Gao in Purinergic Signalling

Article 11 March 2024

Recommended tool compounds and drugs for blocking P2X and P2Y receptors

This review article presents a collection of tool compounds that selectively block and are recommended for studying P2Y and P2X receptor subtypes,...

Christa E. Müller, Vigneshwaran Namasivayam in Purinergic Signalling

Article Open access 02 September 2021

EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report

The inaugural meeting of the EU COST Action CA21130 PRESTO was held in February 2023, at the University of Ferrara, Italy. Our meeting report...

Luke Tattersall, Ankita Agrawal, ... Alison Gartland in Purinergic Signalling

Article Open access 15 July 2023

ATP-P2X₇R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension

Background

Dysfunction of microglia during aging affects normal neuronal function and results in the occurrence of neurodegenerative diseases. Retinal...

Miao Wei, Guowei Zhang, ... Min Ji in Journal of Neuroinflammation

Article Open access 31 July 2023

Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report

PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and...

Luke Tattersall, Elena Adinolfi, ... Ankita Agrawal in Purinergic Signalling

Article Open access 20 February 2024

P2X receptors in the balance between inflammation and pathogen control in sepsis

Luiz Eduardo Baggio Savio in Purinergic Signalling

Article 25 May 2022

Blockage of HCN Channels Inhibits the Function of P2X Receptors in Rat Dorsal Root Ganglion Neurons

Hyperpolarization-activated cyclic nucleotide-gated channels and purinergic P2X receptors play critical roles in the nerve injury-induced pain...

**aolu Lei, Junwei Zeng, ... **aohong Liu in Neurochemical Research

Article 22 January 2022

On P2X receptors in the brain: microvessels. Dedicated to the memory of the late Professor Geoffrey Burnstock (1929–2020)

This tribute article presents selected immunocytochemical and transmission electron microscope data on the location of ATP-gated P2X receptor in the...

Andrzej Loesch in Cell and Tissue Research

Article 23 March 2021

Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy

The development of tumors is a complex pathological process involving multiple factors, multiple steps, and multiple genes. Their prevention and...

Wen-jun Zhang in Purinergic Signalling

Article 09 January 2021

P2X Receptors in Epithelia

2X receptors are ubiquitously expressed in all epithelial tissues but their physiological roles are not well understood. A comprehensive review is...

Jens Leipziger in Studies of Epithelial Transporters and Ion Channels

Chapter 2020

P2 purinergic receptors regulate the progression of colorectal cancer

More and more studies have revealed that P2 purinergic receptors play a key role in the progression of colorectal cancer (CRC). P2X and P2Y...

Wen-jun Zhang, Li-peng Zhang, ... Yi-guan Le in Purinergic Signalling

Article 28 December 2023

Dexmedetomidine Alleviates Acute Stress-Induced Acute Kidney Injury by Attenuating Inflammation and Oxidative Stress via Inhibiting the P2X₇R/NF-κB/NLRP3 Pathway in Rats

This study aimed to investigate the potential protective effects of Dexmedetomidine (DEX) against acute kidney injury (AKI) induced by acute stress...

Haotian Yang, Yuan Zhao, ... Shuai Zhang in Inflammation

Article 19 June 2024

BDNF Participates in Chronic Constriction Injury-Induced Neuropathic Pain via Transcriptionally Activating P2X₇ in Primary Sensory Neurons

Neuropathic pain, resulting from the pathological changes of the somatosensory nervous system, remains a severe public health problem worldwide. The...

Yi Wu, Zhiwen Shen, ... Junhua Li in Molecular Neurobiology

Article 07 May 2021