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Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report
BackgroundProgressive bone pain and fracture and abnormal positron emission tomography combined with a computed tomography are main reasons for the...
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Drug-induced osteoporosis/osteomalacia: analysis in the French and Spanish pharmacovigilance databases
IntroductionOsteomalacia and osteoporosis are two metabolic bone disorders that increase the risk of fracture due to several causes. In terms of...
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Vitamin D and Phosphate Interactions in Health and Disease
Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone...
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Phosphate-Sensing
The blood level of phosphate is tightly regulated in a narrow range. Hyperphosphatemia and hypophosphatemia both lead to the development of diseases,...
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Advances of autoimmune rheumatic diseases related to malignant tumors
BackgroundMalignant neoplasms are a well-recognized global public health concern, with significant impacts on human health and quality of life. The...
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Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series
BackgroundAdefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in...
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Lectures 5 and 6: Musculo-Skeletal System
There are 206 bones in the (adult) body, which comprise about 14% of our body mass, and 700 muscles that should comprise about 40% of our body mass.
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Extracellular Phosphate, Inflammation and Cytotoxicity
Phosphorus is an essential nutrient that plays a crucial role in various biological processes, including cell membrane integrity, synthesis of...
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Real life evaluation of the multi-organ effects of Lumacaftor/Ivacaftor on F508del homozygous cystic fibrosis patients
BackgroundLumacaftor/Ivacaftor (LUM-IVA), a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector-potentiator combination,...
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Water and Electrolytes Disorders in Oncology
Introduction: water and electrolyte disorders are frequently found in oncologic patients since they are usually exposed to diverse symptoms,...
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Bone Tumors: An Overview
Bone tumors account for less than 1% of all tumors. Most patients come with a history of progressive pain. Age and location of tumors are important...
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Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health
Consumption of high-quality animal proteinAnimal protein plays an important role in improving human nutrition, growth, development, and healthHealth....
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Medical Imaging Manifestation of Skeletal Fluorosis
There are three types of endemic fluorosis, namely drinking water type, coal-burning type, and brick-tea type of endemic fluorosis. With skeletal...
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The regulation of FGF23 under physiological and pathophysiological conditions
Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D...
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Phosphate Metabolism: From Physiology to Toxicity
Systemic phosphate homeostasis is tightly controlled by the delicate cross-organ talk among intestine, kidney, bone, and parathyroid glands. The...