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Oligoclonal Bands: Isoelectric Focusing and Immunoblotting, and Determination of κ Free Light Chains in the Cerebrospinal Fluid
A variety of inflammatory diseases of the central nervous system ranging from an autoimmune to infectious pathophysiology are characterized by...
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Antibodies from Multiple Sclerosis Brain Identified Epstein-Barr Virus Nuclear Antigen 1 & 2 Epitopes which Are Recognized by Oligoclonal Bands
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), the etiology of which is poorly...
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The Cerebrospinal Fluid Presentations of Neuro-Behçet Disease
In parenchymal neuro-Behçet disease (NBD), CSF opening pressure is usually normal. CSF pleocytosis is usually less than 200/mm3. Pleocytosis could be...
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Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders
Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS). Although no such differences in MS blood total...
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Toward an automatic tool for oligoclonal band detection in cerebrospinal fluid and tears for multiple sclerosis diagnosis: lane segmentation based on a ribbon univariate open active contour
The latest revision of multiple sclerosis diagnosis guidelines emphasizes the role of oligoclonal band detection in isoelectric focusing images of...
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Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder
BackgroundDown syndrome regression disorder is a symptom cluster consisting of neuropsychiatric regression without cause. This study evaluated the...
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LGI1 antibody-associated encephalitis without evidence of inflammation in CSF and brain MRI
ObjectiveThis study aimed to explore the frequency and distinct characteristics of adult patients with LGI1 antibody-associated encephalitis in the...
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Evaluation of inflammatory acquired demyelinating syndromes in children: a single-center experience
To evaluate the clinical and neuroimaging features of pediatric acquired demyelinating syndromes (ADS) in a tertiary pediatric neurology clinic in...
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Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis
A hallmark of the inflammatory response in multiple sclerosis (MS) is the presence of intrathecal Immunoglobulin G (IgG) antibodies and oligoclonal...
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Rare case of multifocal extradural and intramedullary neurosarcoidosis without pulmonary involvement: a case report and literature review
IntroductionSarcoidosis is a multisystem disease characterized histologically by noncaseating granulomas. Localization of sarcoidosis to the CNS is...
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Progression free survival of myeloma patients who become IFE-negative correlates with the detection of residual monoclonal free light chain (FLC) by mass spectrometry
Deeper responses are associated with improved survival in patients being treated for myeloma. However, the sensitivity of the current blood-based...
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The Search for Immunological Biomarkers in Type 1 Diabetes Mellitus (T1DM) and Multiple Sclerosis (MS): Th40 Cells Provide a Common Autoimmune Link
Biomarkers to predict autoimmune disease onset or predict progression are sorely lacking. A specific T cell subset present in peripheral blood of...
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Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients
BackgroundComprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale...
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Multiple Sclerosis
Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disorder of the central nervous system (CNS) characterized by myelin and...
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Immune-mediated cerebellitis following SARS-CoV-2 infection—a case report and review of the literature
The coronavirus disease 2019 (COVID-19) can be associated with a wide variety of neurological manifestations. Some of these manifestations might...
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A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin
We report the case of a 22-year-old woman presenting with an acute onset of dizziness, gait dysbalance and blurred vision. Magnetic resonance imaging...
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Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases
Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to...
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Blood and CSF anti-neuronal antibodies testing in psychotic syndromes: a retrospective analysis from a tertiary psychiatric hospital
A Consensus of Psychoimmunology Experts ( Pollak et al., 2019) established a set of red flags and proposed diagnostic criteria for psychosis of...
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Differentially Expressed Erythrocyte Proteins in Neuromyelitis Optica Spectrum Disorders and Their Functional Annotation Using DAVID Bioinformatics Tool
AbstractNeuromyelitis optica spectrum disorders (NMOSD) are autoimmune disorders affecting central nervous system with immunoglobulin G positivity to...
