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Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2
Polycomb repressive complex 2 (PRC2) interacts with RNA in cells, but there is no consensus on how RNA regulates PRC2 canonical functions, including...
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Functional insight into a neurodevelopmental disorder caused by missense variants in an RNA-binding protein, RBM10
The RNA-binding motif protein 10, RBM10, is an RNA splicing regulator essential for development. Loss-of-function RBM10 variants are associated with...
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A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and ubiquitously expressed member of the heterogeneous nuclear...
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OCT4’s role and mechanism underlying oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative...
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ES Cells or iPS Cells, that Is the Question
There is increasing evidence that microRNA (miRNA) genes regulate cell self-renewal and pluripotency in stem cells. miR-302, miR-209, and miR-371...
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Oct4 facilitates chondrogenic differentiation of mesenchymal stem cells by mediating CIP2A expression
Bone development and cartilage formation require strict modulation of gene expression for mesenchymal stem cells (MSCs) to progress through their...
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PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours
The protein arginine methyltransferase 5 (PRMT5), which is highly expressed in tumour tissues, plays a crucial role in cancer development. However,...
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Role of Long Intergenic Noncoding RNAs in Cancers with an Overview of MicroRNA Binding
Long intergenic noncoding RNAs are transcripts originating from the regions without annotated coding genes. They are located mainly in the nucleus...
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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model
Although the beneficial effects of curcumin, extracted from rhizomes of the ginger family genus Curcuma , on the repair and regeneration of nerves...
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The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory...
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Role of OCT4 in Glioblastoma
OCT4 (Octomer binding transcription factor 4) is also called POU5F1-POU domain Class 5, transcription factor 1. The POUF51 gene encodes OCT4 (Takeda...
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circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression
BackgroundRecent evidence reveals the emerging functions of circular RNA (circRNA) and protein glycosylation in cancer progression. However, the...
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Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor
BackgroundProstate cancer is dependent on androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) has proven effective in targeting...
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RNA analysis based on a small number of manually isolated fixed cells (RNA-snMIFxC) to profile stem cells from human deciduous tooth-derived dental pulp cells
BackgroundExpression of stemness factors, such as octamer-binding transcription factor 3/4 ( OCT3/4 ), sex determining region Y-box 2 ( SOX2 ), and...
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Chromatin Remodeling and Organization
In this chapter, we will learn that nucleosome positioning around TSS regions has an important role on coordinated gene activation of promoter...
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Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes
Single molecule FRET (Forster resonance energy transfer) is very powerful method for studying biomolecular binding dynamics and conformational...
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Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women in China. In previous studies, Sestrin2 was...
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Histone Chaperones in Cancer
Histone epigenetics has three layers including histone modifications, histone variants, and histone chaperones. Unlike the first two components,...
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Histone Chaperones in Cancer
Histone epigenetics has three layers including histone modifications, histone variants, and histone chaperones. Unlike the first two components,...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...