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Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB
Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which currently have no...
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Eukaryotic Ribosome assembly and Nucleocytoplasmic Transport
The process of eukaryotic ribosome assembly stretches across the nucleolus, the nucleoplasm and the cytoplasm, and therefore relies on efficient...
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Melatonin-Driven NLRP3 Inflammation Inhibition Via Regulation of NF-κB Nucleocytoplasmic Transport: Implications for Postoperative Cognitive Dysfunction
The aseptic inflammatory response of the central nervous system is one of the important causes of neurodegenerative diseases in individuals and is...
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Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway
Nucleocytoplasmic transport (NCT) decline occurs with aging and neurodegeneration. Here, we investigated the NCT pathway in models of amyotrophic...
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Measuring Protein Nuclear Transport via a Dual Reporter in iPSC-Derived Neurons
Nucleocytoplasmic transport (NCT) plays a critical role in maintaining cellular homeostasis, and its dysregulation has been shown to be implicated in...
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SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution
The nuclear RNA-binding protein TDP-43 forms abnormal cytoplasmic aggregates in the brains of amyotrophic lateral sclerosis (ALS) and frontotemporal...
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Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted...
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The Hitchhiker’s Guide to Nucleocytoplasmic Trafficking in Neurodegeneration
The widespread nature of nucleocytoplasmic trafficking defects and protein accumulation suggests distinct yet overlap** mechanisms in a variety of...
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Optogenetic Control of Nucleocytoplasmic Protein Transport
The transport of proteins between the nucleus and the cytosol is a vital process regulating cellular activity. The ability to spatiotemporally...
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Genetic Modulators in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is known as one of the fatal diseases among the neurodegenerative disorders. It is characterized by the...
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Assembly and Evolution of Poxviruses
Poxvirus assemblyPoxvirus assembly has been an intriguing area of research for several decades. While advancements in experimental techniques...
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Nuclear Pore Dysfunction in Neurodegeneration
The nuclear pore complex (NPC) is a large multimeric structure that is interspersed throughout the membrane of the nucleus and consists of at least...
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Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are...
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Autophagy Dysfunction in ALS: from Transport to Protein Degradation
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of...
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Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy
Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure leading to mortality. The main locus of ALS is motor...
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PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression
Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer...
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Analysis of Differentially Expressed Genes between Paroxysmal and Persistent Atrial Fibrillation
AbstractAtrial fibrillation is one of the most common arrhythmias in adults. There is a significant difference in the curative effect between...
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Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation
Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP or TDP-43) is a key pathological feature of several...
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Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
BackgroundCytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and...
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Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease
BackgroundDifferent neural subtypes are selectively lost in diverse neurodegenerative diseases. Huntington’s disease (HD) is an inherited...
