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Notch Cell Signaling Pathway and Brain Tumors
The Notch signaling pathway is highly conserved in most organisms (Artavanis-Tsakonas et al. 1999). There are four different types of Notch receptors...
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Tanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway
BackgroundPsoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the...
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The Notch pathway regulates autophagy after hypoxic–ischemic injury and affects synaptic plasticity
Following neonatal hypoxic–ischemia (HI) injury, it is crucial factor to reconstruct neural circuit and maintain neural network homeostasis for...
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TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Extracellular matrix proteins are associated with metabolically healthy adipose tissue and regulate inflammation, fibrosis, angiogenesis, and...
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The role of Hedgehog and Notch signaling pathway in cancer
Notch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like...
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Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway
BackgroundThe purpose of this study was to investigate the role of hsa_circRNA_102051 in colorectal cancer (CRC) and its effect on the stemness of...
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Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway
PurposeWe aimed to investigate the role of ubiquilin-4 in predicting the immunotherapy response in gastric cancer.
MethodsRetrospective...
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Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer
Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the...
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Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway
Vascular lesions frequently arise as complication in patients diagnosed with diabetes mellitus (DM). Presently, percutaneous coronary intervention...
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LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo
Long noncoding RNAs (lncRNAs) have been demonstrated to participate in neuroblastoma cisplatin resistance and tumorigenesis. LncRNA LINC00460 was...
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Oncogenic signaling pathway mediated by Notch pathway-related genes induces immunosuppression and immunotherapy resistance in hepatocellular carcinoma
The Notch pathway is a highly conserved signaling pathway involved in the regulation of cell proliferation and differentiation. However, the...
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Gastrodin Regulates the Notch-1 Signal Pathway via Renin–Angiotensin System in Activated Microglia
Notch-1 and renin angiotensin system (RAS) are involved in microglia activation. It has been reported that gastrodin inhibited inflammatory responses...
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A disulfiram derivative against lung cancer via the Notch signaling pathway without neurotoxicity and hepatotoxicity
The exploration of novel anti-lung cancer small-molecule drugs is important for drug resistance and adverse effects of chemotherapeutic drugs in...
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Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver
The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located...
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Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway
BackgroundIt is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited...
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Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition
BackgroundIntrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the...
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Examining the contribution of Notch signaling to lung disease development
Notch pathway is a widely observed signaling system that holds pivotal functions in regulating various developmental cellular functions and...
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Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway
The aim of this study was to investigate the underlying protective mechanisms of asiaticoside (AS) against liver fibrosis (LF) both in vivo and in...
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Diffuse subtype-specific gastric carcinogenesis associated with dysregulation of Notch signaling pathways
Gastric tumors are the third leading cause of cancer-related mortality worldwide. This study investigates the effects of Notch signaling pathway...
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Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation
BackgroundEncystation of the protoscoleces (PSCs) of Echinococcus granulosus is the main cause of secondary hydatid dissemination in the...
