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A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson’s disease
In Parkinson’s disease (PD), cardiovascular dysautonomia accumulates with disease progression, but studies are lacking on the natural history behind...
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Delayed orthostatic hypotension in Parkinson’s disease
Orthostatic hypotension (OH) is relatively common in the early stage of Parkinson’s disease (PD). It is divided into delayed OH and classical OH....
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Clinical Trials for Orthostatic Hypotension in Parkinson’s Disease and Other Synucleinopathies
Neurogenic orthostatic hypotension (nOH) is one of the most debilitating nonmotor symptoms in patients with Parkinson disease and other...
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Transient alteration of consciousness in spinal cord injury secondary to Baclofen use: a case report
IntroductionOral baclofen is commonly used for spasticity management, especially with neurogenic bladder in spinal cord injury (SCI). A less common...
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Recurrent syncope secondary to autonomic dysfunction in spinal cord injury: a case report
High-level spinal cord injuries are often associated with autonomic impairment, which can result in orthostatic hypotension and syncope. Persistent...
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Combination therapy of midodrine and droxidopa for refractory hypotension in heart failure with preserved ejection fraction per a pharmacist’s proposal: a case report
BackgroundPatients with chronic heart failure (CHF) are often treated using many diuretics for symptom relief; however, diuretic use may have to...
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Autonomic Function and Electroacupuncture
Effectiveness of acupuncture in regulating suboptimal autonomic function and its mechanisms are investigated for several decades by the scientific...
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Corneal confocal microscopy may help to distinguish Multiple System Atrophy from Parkinson’s disease
Multiple system atrophy (MSA) and Parkinson’s disease (PD) have clinical overlap** symptoms, which makes differential diagnosis difficult. Our...
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Construct validity of the international standards to document remaining autonomic function after spinal cord injury (ISAFSCI) (1st edition)
Study designObservational study.
ObjectivesTo assess the construct validity of the International Standards to Document Remaining Autonomic Function...
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Autonomic impairment is not explained by neurological level of injury or motor-sensory completeness
Study designCross-sectional study.
ObjectivesDetermine how well common clinical assessments of level and completeness of injury are correlated with...
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A Systematic Review of the Spectrum and Prevalence of Non-motor Symptoms in Multiple System Atrophy
BackgroundPatients with Multiple System Atrophy (MSA) frequently report non-motor symptoms, and several research groups have highlighted this.
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Dysautonomia and REM sleep behavior disorder contributions to progression of Parkinson’s disease phenotypes
Non-motor symptoms of Parkinson’s disease (PD) such as dysautonomia and REM sleep behavior disorder (RBD) are recognized to be important prodromal...
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A Review on the Clinical Diagnosis of Multiple System Atrophy
Multiple system atrophy (MSA) is a rare, adult-onset, progressive neurodegenerative disorder with major diagnostic challenges. Aiming for a better...
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Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the...
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Lecture 22: Control of Blood Pressure
Blood flows only when its pressure is higher at one place than in another, and it flows always from the place of higher pressure towards the place of...
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Autonomic Dysfunction in Parkinson’s Disease
Recognition of the importance of nonmotor dysfunction as a component of Parkinson’s disease has exploded over the past three decades. Autonomic...
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Symptomatic Care in Multiple System Atrophy: State of the Art
Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a...
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Impact of Space Pharmaceuticals on Cardiovascular System
After half a century full of exciting mix of space flight success and failures, space scientists, governments, and entrepreneurs have learned a...
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Impact of Space Pharmaceuticals on Cardiovascular System
After half a century full of exciting mix of space flight success and failures, space scientists, governments, and entrepreneurs have learned a...