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Non-swarm-based computational approach for mining cancer drug target modules in protein interaction network
Cancer is a lethal disease that drew the entire world over the past decades. Currently, numerous researches focused on these cancer treatments. Most...
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A spatial transformation-based CAN model for information integration within grid cell modules
The hippocampal-entorhinal circuit is considered to play an important role in the spatial cognition of animals. However, the mechanism of the...
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Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish
The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our...
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The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug...
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Primary Visual Cortex Modules in Mammals
The structural and functional units of the visual cortex are columns (modules), which are regularly distributed in the tangential plane of the cortex...
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Exploring interactions between parasites and their hosts in the Pantanal floodplain using an ecological network approach
The study of host–parasite interactions is essential to understand the role of each host species in the parasitic transmission cycles in a given...
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Microbial active functional modules derived from network analysis and metabolic interactions decipher the complex microbiome assembly in mangrove sediments
BackgroundThe metabolic interactions of microbes significantly affect the assembly of microbial communities that play important roles in...
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Integrative Analysis of DNA Methylation and Gene Expression Data Identifies Potential Biomarkers and Functional Epigenetic Modules for SARS-CoV-2
To integrate gene expression and DNA methylation data and find the potential role of DNA methylation in the invasion and replication of severe acute...
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Network expansion of genetic associations defines a pleiotropy map of human cell biology
Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of...
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A network-based machine-learning framework to identify both functional modules and disease genes
Disease gene identification is a critical step towards uncovering the molecular mechanisms of diseases and systematically investigating complex...
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Exploration of Positive and Negative Schizophrenia Symptom Heterogeneity and Establishment of Symptom-Related miRNA-mRNA Regulatory Network: Based on Transcriptome Sequencing Data
Schizophrenia (SCZ) symptoms can be classified as positive and negative ones, each of which has distinct traits and possibly differences in gene...
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Re-Exploring the Inflammation-Related Core Genes and Modules in Cerebral Ischemia
The genetic transcription profile of brain ischemic and reperfusion injury remains elusive. To address this, we used an integrative analysis approach...
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Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy
Over 50 million people worldwide are affected by epilepsy, a common neurological disorder that has a high rate of drug resistance and diverse...
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Identification of potential biological processes and key genes in diabetes-related stroke through weighted gene co-expression network analysis
BackgroundType 2 diabetes mellitus (T2DM) is an established risk factor for acute ischemic stroke (AIS). Although there are reports on the...
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Integrated proteomic and metabolomic modules identified as biomarkers of mortality in the Atherosclerosis Risk in Communities study and the African American Study of Kidney Disease and Hypertension
BackgroundProteins and metabolites are essential for many biological functions and often linked through enzymatic or transport reactions. Individual...
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Network state transitions during cortical development
Mammalian cortical networks are active before synaptogenesis begins in earnest, before neuronal migration is complete, and well before an animal...
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Weighted Gene Co-expression Network Analysis and Machine Learning Validation for Identifying Major Genes Related to Sjogren’s Syndrome
Sjogren’s syndrome (SS) is an autoimmune disorder characterized by dry mouth and dry eyes. Its pathogenic mechanism is currently unclear. This study...
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Network Evolution Model-based prediction of tumor mutation burden from radiomic-clinical features in endometrial cancers
BackgroundEndometrial Cancer (EC) is one of the most prevalent malignancies that affect the female population globally. In the context of...
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Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks
BackgroundGenome-wide Association Studies (GWAS) aims to uncover the link between genomic variation and phenotype. They have been actively applied in...
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Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets
Corona virus disease 2019 (COVID-19) increases the risk of cardiovascular occlusive/thrombotic events and is linked to poor outcomes. The underlying...
