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Delay modulates the immune response to nerve repair
Effective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within...
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Tissue Engineering for Sciatic Nerve Repair: Review of Methods and Challenges
PurposeThe primary objective of this study was to offer a thorough examination of the various tissue engineering approaches employed in sciatic nerve...
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Advances in Exosome-Based Therapies for the Repair of Peripheral Nerve Injuries
Peripheral nerve injuries (PNIs) are the term used to describe injuries that occur to the nerve fibers of the peripheral nervous system (PNS). Such...
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Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway
BackgroundMaintaining the repair phenotype of denervated Schwann cells in the injured distal nerve is crucial for promoting peripheral nerve...
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Biological nerve conduit model with de-epithelialized human amniotic membrane and adipose-derived mesenchymal stem cell sheet for repair of peripheral nerve defects
In this study, a biological conduit, consisting of an adipocyte-derived mesenchymal stem cell (AdMSCs) sheet and amniotic membrane (AM), was designed...
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Clinically relevant small-molecule promotes nerve repair and visual function recovery
Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system...
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Nerve Regeneration
Nerve injuries may result in neurological dysfunction or even permanent disability, which poses various challenges to physicians. In the peripheral...
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Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition
Nerve tissue regeneration is a significant problem. After neural diseases and damage such as spinal cord injury (SCI), the accumulation of...
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Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries
We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve segment are the most common type of traumatic injury to...
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Spontaneous Regeneration after Hypoglossal Nerve Injury with Long Nerve Resection in Rats
Spontaneous neural regeneration may occur in peripheral nerve injury after nerve resection with a relatively short gap, whereas regeneration does not...
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Nerve Regeneration Through Differentiation of Endometrial-Derived Mesenchymal Stem Cells into Nerve-Like Cells Using Polyacrylonitrile/Chitosan Conduit and Berberine in a Rat Sciatic Nerve Injury Model
Nervous injuries are common in humans. One of the most advanced treatment methods is neural tissue engineering. This research aims to utilize...
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Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
The adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. This is related to the unique...
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Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells
Although evidence has accumulated to indicate that Schwann cells (SCs) differentiate into repair SCs (RSCs) upon injury and that the unique phenotype...
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Exogenous NT-3 Promotes Phenotype Switch of Resident Macrophages and Improves Sciatic Nerve Injury through AMPK/NF-κB Signaling Pathway
Neurotrophin-3 (NT-3) is an important family of neurotrophic factors with extensive neurotrophic activity, which can maintain the survival and...
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DHI Increases the Proliferation and Migration of Schwann Cells Through the PI3K/AKT Pathway and the Expression of CXCL12 and GDNF to Promote Facial Nerve Function Repair
The facial nerve is one of the vulnerable nerves in otolaryngology. Repair and recovery of facial nerve injury have a high priority in clinical...
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Types of Short-Duration Electrical Stimulation-Induced Efficiency in the Axonal Regeneration and Recovery: Comparative in Vivo Study in Rat Model of Repaired Sciatic Nerve and its Tibial Branch after Transection Injury
The restoration of adequate function and sensation in nerves following an injury is often insufficient. Electrical stimulation (ES) applied during...
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Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury
Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism...
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The Pulsed Nd:YAG Laser Therapy Enhanced Nerve Regeneration via Apoptosis Inhibition in a Rat Crushed Sciatic Nerve Model
The study was aimed to validate the efficacy of the pulsed Nd:YAG laser on nerve regeneration in a rat sciatic nerve crushed model. 54 Wistar rats...
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Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury
Nerve transection requires surgical intervention to restore function. The standard of care involves coaptation when a tension-free repair is...
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The Emerging Role of Satellite and Schwann Cells of the Peripheral Neuroglial System in Nerve Repair
The peripheral nervous system (PNS) has distinct neuroglial system that is different from the central nervous system glial population. The PNS...