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Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis
Type-2 diabetes mellitus (T2DM) is associated with neuroinflammation and cognitive decrement. Necroptosis programmed necrosis is emerging as the...
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Necrostatin-1s Suppresses RIPK1-driven Necroptosis and Inflammation in Periventricular Leukomalacia Neonatal Mice
Periventricular leukomalacia (PVL), a predominant form of brain injury in preterm survivors, is characterized by hypomyelination and microgliosis and...
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Necroptosis inhibitors: mechanisms of action and therapeutic potential
Necroptosis is a type of programmed cell death that is morphologically similar to necrosis. This type of cell death is involved in various...
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SARS-CoV-2 envelope protein induces necroptosis and mediates inflammatory response in lung and colon cells through receptor interacting protein kinase 1
SARS-CoV-2 Envelope protein (E) is one of the crucial components in virus assembly and pathogenesis. The current study investigated its role in the...
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Necrostatin-1 as a Neuroprotectant
Necrostatin-1 (Nec-1) is an inhibitor of necroptosis, a form of regulated nonapoptotic cell death pathway. It acts via allosteric blockade of...
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The Role of Necroptosis in Cerebral Ischemic Stroke
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disability worldwide. Due to...
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Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and leaky, erythrocytes are...
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Necroptosis and Its Involvement in Various Diseases
Necroptosis is a regulated form of cell death involved in the development of various pathological conditions. In contrast to apoptosis, plasma...
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Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer
Helicobacter pylori , particularly cytotoxin-associated gene A (CagA)-positive strains, plays a key role in the progression of gastric cancer (GC)....
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RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis
BackgroundRheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and...
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Necrostatin-1 as a Neuroprotectant
Necrostatin-1 (Nec-1) is an inhibitor of necroptosis, a form of regulated nonapoptotic cell death pathway. It acts via allosteric blockade of...
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Approaches to Evaluating Necroptosis in Virus-Infected Cells
The immune system functions to protect the host from pathogens. To counter host defense mechanisms, pathogens have developed unique strategies to...
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Non-apoptotic Cell Death Control of Neutrophil Extracellular Trap Formation
Neutrophil extracellular traps (NETs) are networks of chromatin and microbicidal proteins released by neutrophils in response to infection and tissue...
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Methods to Study the Effect of IKK Inhibition on TNF-Inducing Apoptosis and Necroptosis in Cultured Cells
The engagement of TNF on TNFR can result in cell survival or cell death depending on the different complex formation downstream this interaction....
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The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice
BackgroundIncreasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated...
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Protective Effect of a Novel RIPK1 Inhibitor, Compound 4–155, in Systemic Inflammatory Response Syndrome and Sepsis
Excessive inflammatory response is a critical pathogenic factor for the tissue damage and organ failure caused by systemic inflammatory response...
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Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis
BackgroundAcute lung injury (ALI) is a common and serious complication of sepsis with high mortality. Ferroptosis, categorized as programmed cell...
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Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes
Pancreatic beta-cell death has been established as a critical mediator in the progression of type 1 and type 2 diabetes mellitus. Beta-cell death is...
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Environmental allergens trigger type 2 inflammation through ripoptosome activation
Environmental allergens, including fungi, insects and mites, trigger type 2 immunity; however, the innate sensing mechanisms and initial signaling...
