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Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system development by regulating angiogenesis and axon guidance cues....
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In silico molecular docking of SARS-CoV-2 surface proteins with microbial non-ribosomal peptides: identification of potential drugs
Outbreak of COVID-19 by SARS-CoV-2 infection caused severe acute respiratory syndrome that has been declared a public health emergency of...
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Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma
BackgroundDespite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of...
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Screening of Antibiotic Gene Clusters in Microorganisms Isolated from Wood
The biosphere of Earth is made up of a variety of ecosystems governed by complex biological interactions, some of them mediated by microbial...
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The Complete Genomic Sequence of Microbial Transglutaminase Producer, Streptomyces mobaraensis DSM40587
Actinomycetes are remarkable natural sources of active natural molecules and enzymes of considerable industrial value. Streptomyces mobaraensis is...
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Draft genome sequence of antimicrobial producing Paenibacillus alvei strain MP1 reveals putative novel antimicrobials
ObjectiveA Paenibacillus strain isolated in previous research exhibited antimicrobial activity against relevant human pathogens including Staphylococc...
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Plant Endophytes: A Treasure House of Antimicrobial Compounds
Recent decades have witnessed a significant progress in identifying novel and economically viable therapeutic compounds from natural resources. There...
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Analysis of the Genomic Sequences and Metabolites of Bacillus velezensis YA215
Discovering more novel antimicrobial compounds has become a keen research problem. In this study, YA215 genome was sequenced by the Illumina...
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Non-enzymatic reactions in biogenesis of fungal natural products
Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. Decades of studies on the...
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Strategies for Enhancing the Production of Echinocandin
Fungi are well known for their ability to naturally produce a multitude of secondary metabolites (SMs) which act as a weapon of defense to protect...
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Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity
Chinese cordyceps, also known as Dong-Chong-**a-Cao, is widely recognized as a famous precious tonic herb, and used as traditional Chinese medicine...
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The effect of craniocervical flexion and neck endurance exercises plus pulmonary rehabilitation on pulmonary function in spinal cord injury: a pilot single-blinded randomised controlled trial
Study designRandomised controlled trial with computerised allocation, assessor blinding and intention-to-treat analysis.
ObjectiveThis study wanted...
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Bioprospection of Marine Sponge Microbiome for Bioactive Metabolites Employing Advanced Metagenomics Tools
The marine environment is an invaluable natural goods and biomaterials resource. Sponges, abundant members of marine benthic ecosystems, are a...
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Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Controlling and treating biofilm-related infections is challenging because of the widespread presence of multidrug-resistant microbes. Biofilm, a...
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Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation
BackgroundTetramates or tetramic acid-containing compounds (TACs) are a group of bioactive natural products featuring a pyrrolidine-2,4-dione ring...
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Complete Genome Sequence of Streptomyces sp. HP-A2021, a Promising Bacterium for Natural Product Discovery
Streptomyces are one of the most prolific sources of bioactive and structurally diverse secondary metabolites for natural product drug discovery....
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Chemical Diversity in Fungi: Strategies to Mitigate Antimicrobial Resistance
The development of multidrug resistance (MDR) in bacterial pathogens has been the prime challenge to solve for researchers across the globe. The...
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Global analysis of the biosynthetic chemical space of marine prokaryotes
BackgroundMarine prokaryotes are a rich source of novel bioactive secondary metabolites for drug discovery. Recent genome mining studies have...
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Metabolome and Genome Analysis of a Novel Endophytic Fungus Aureobasidium pullulans KB3: Discovery of Polyketones and Polyketone Biosynthesis Pathway
Endophytic fungi associated with plants may contain undiscovered bioactive compounds. Under standard laboratory conditions, most undiscovered...
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Uncovering the Desert Fungal Enigma: An Attractive Resource for Biopharmaceuticals
Fungi reside everywhere on the earth, from the Arctic to the tropics. Fungi are described as an exceptionally capable organism living in extremely...