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USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis
BackgroundEndothelial-to-Mesenchymal Transformation (EndMT) plays key roles in endothelial dysfunction during the pathological progression of...
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NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models
Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc)...
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METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer
BackgroundN6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the...
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Dysregulation of long noncoding RNA MEG3 and NLRC5 expressions in patients with relapsing-remitting multiple sclerosis: is there any correlation?
Long noncoding RNA MEG3 and NLRC5 genes are both involved in the immune system and the regulation of NLRC5 by MEG3 is documented in rheumatoid...
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Promotion on NLRC5 upregulating MHC-I expression by IFN-γ in MHC-I–deficient breast cancer cells
Breast cancer is the most dominant cancer in women and the second most frequent cancer in the general population worldwide. NLRC5 critically...
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The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several genes that were later grouped into the family were already known...
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LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression
BackgroundLATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of LATS1/2 in EC progression remains...
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The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis
BackgroundNucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular sensors of pathogens and molecules from damaged...
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Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells
BackgroundBats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate...
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Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance
Major histocompatibility complex (MHC) class I and class II molecules play critical roles in the activation of the adaptive immune system by...
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NLRC5: potential novel non-invasive biomarker for predicting and reflecting the progression of IgA nephritis
BackgroundThe nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems....
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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Immune Homeostasis: A Novel Example of Teamwork
All living organisms must maintain homeostasis to survive, reproduce, and pass their traits on to the next generation. If homeostasis is not...
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BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness
Cancer is one of the main causes of human death. Here, we focus on the B-cell lymphoma 7 protein family member B (BCL7B) gene, an accessory subunit...
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Loss of heterozygosity impacts MHC expression on the immune microenvironment in CDK12-mutated prostate cancer
BackgroundIn prostate cancer (PCa), well-established biomarkers such as MSI status, TMB high, and PDL1 expression serve as reliable indicators for...
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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with...
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Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing
Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with...
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Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
BackgroundDespite immunotherapies having revolutionized the treatment of advanced cutaneous melanoma, effective and durable responses were only...
