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Nanoliposomal irinotecan plus fluorouracil and folinic acid as a second-line treatment option in patients with metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study
BackgroundAccording to the NAPOLI-1 trial, nanoliposomal irinotecan (nal-IRI) plus fluorouracil/folinic acid (5-FU/LV) showed improved overall...
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Haematological and biochemical abnormalities in hunting dogs infected with Acanthocheilonema reconditum, associated risk factors, and a European overview
Acanthocheilonema reconditum is a filarial parasite transmitted by arthropods (fleas, lice, and ticks) that infect dogs. There is minimal published...
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Salmonella infections in Denmark from 2013–2022 with focus on serotype distribution, invasiveness, age, sex, and travel exposition
PurposeTo analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022.
MethodsConfirmed cases of Salmonella enterica ...
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Analysis of biosimilars consumption in an Italian Local Health Authority
Biosimilar drugs offer an opportunity for all global healthcare systems because they provide significant cost savings while ensuring equal efficacy...
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Biomarker analysis for patients with pancreatic cancer treated with nanoliposomal irinotecan plus 5-fluorouracil/leucovorin
BackgroundNanoliposomal irinotecan plus fluorouracil/leucovorin (5-FU/LV) is a standard second-line therapy for patients with pancreatic cancer....
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Diagnostic challenges for Aelurostrongylus abstrusus infection in cats from endemic areas in Italy
BackgroundThe lungworm Aelurostrongylus abstrusus infects wild and domestic feline species worldwide and is considered a primary respiratory...
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FOLFOX regimen after failure of fluorouracil and leucovorin plus nanoliposomal-irinotecan therapy for advanced pancreatic cancer: a retrospective observational study
BackgroundFluorouracil, leucovorin (5FU/LV), and nanoliposomal-irinotecan (nal-IRI) combination therapy has been established as the second-line...
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SARS-CoV-2 complete genome sequencing from the Italian Campania region using a highly automated next generation sequencing system
BackgroundSince the first complete genome sequencing of SARS-CoV-2 in December 2019, more than 550,000 genomes have been submitted into the GISAID...
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Molecular characterization of canine filarioids in a previously non-endemic area of Rio de Janeiro State, Brazil
Dirofilaria immitis is the causative agent of canine heartworm disease, a severe health problem in dogs, especially in coastal areas of tropical and...
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Biological and molecular characterization of a new potexvirus isolated from Adenium obesum
Adenium obesum plants showing virus-like symptoms were collected in several regions of Brazil. Mottling symptoms like those observed in symptomatic...
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Mitochondrial Dysfunction in Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a wide variation in the type and severity of symptoms. Commonly,...
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Treatment sequences and prognostic/predictive factors in metastatic pancreatic ductal adenocarcinoma: univariate and multivariate analyses of a real-world study in Europe
BackgroundReal-world data on treatment patterns/outcomes for metastatic pancreatic cancer (mPAC) are limited. This study aims to assess real-world...
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Oxidative stress and neuroimmune proteins in a mouse model of autism
Oxidative stress including decreased antioxidant enzyme activities, elevated lipid peroxidation, and accumulation of advanced glycation end products...
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Atypical case of subcutaneous filariosis in a cat caused by Dirofilaria immitis
Subcutaneous dirofilariosis is a well-known disease caused mainly by Dirofilaria repens and described in several mammalian species including humans,...
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From Where? Synaptic Tagging Allows the Nucleus Not to Care
Most of us now accept that the formation of long-lasting memories requires the de novo transcription of plasticity-related proteins. It is also...
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First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate cancer cells, and...
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The Role of Endogenous Opioids in Cardioprotection
The opioid system involves opioid receptors (OPRs) and endogenous opioid peptides. This chapter will focus on the distribution of OPRs in the...
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Parallel administration of nanoliposomal irinotecan and levo-leucovorin for pancreatic cancer
BackgroundNanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil (5-FU)/ levo -leucovorin ( Levo -LV) was approved for unresectable pancreatic cancer...
