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Defining albumin as a glycoprotein with multiple N-linked glycosylation sites
BackgroundGlycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma...
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A Novel Integrated Pipeline for Site-Specific Quantification of N-glycosylation
The site-specific N-glycosylation changes of human plasma immunoglobulin gamma molecules (IgGs) have been shown to modulate the immune response and...
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Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas
Pancreatic cancer is among the most malignant cancers, and thus early intervention is the key to better survival outcomes. However, no methods have...
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2-Deoxy-D-glucose inhibits lymphocytic choriomeningitis virus propagation by targeting glycoprotein N-glycosylation
BackgroundIncreased glucose uptake and utilization via aerobic glycolysis are among the most prominent hallmarks of tumor cell metabolism....
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Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation
BackgroundA better diagnostic marker is in need to distinguish breast cancer from suspicious breast lesions. The abnormal glycosylation of...
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The role of N-linked glycosylation in proteolytic processing and cell surface transport of the Cedar virus fusion protein
BackgroundN-linked glycans on viral glycoproteins have been shown to be important for protein expression, processing and intracellular transport. The...
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Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression
BackgroundChanges in protein glycosylation are widely observed in tumor cells. N -glycan branching through adding β1,6-linked N -acetylglucosamine...
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Producing Biologics with Defined N-Glycosylation in Plants
The proper glycosylation of glycoproteins is important for their structure and function. This is an especially important consideration when choosing...
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Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain
BackgroundNeuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A...
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Comparison of self-sampling blood collection for N-glycosylation analysis
ObjectiveSelf-sampling of capillary blood provides easier sample collection, handling, and ship** compared to more invasive blood sampling via...
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MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients
Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several...
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Mass Spectrometry-Based Methods for Immunoglobulin G N-Glycosylation Analysis
Mass spectrometry and its hyphenated techniques enabled by the improvements in liquid chromatography, capillary electrophoresis, novel ionization,...
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Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels
Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these...
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The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
N -linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of...
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Congenital Disorders of Glycosylation (CDG) of N-Glycoprotein
Among the PTMs, the N-Glycosylation is the representative sugar–amino acid linkages of glycoproteins. Glycans attached to protein by a GlcNAcβ1-N-Asn...
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N-Glycan and O-Glycan Glycosylation in Eukaryotes
Currently, it is known that approximately 27% of all human proteins are found in N-glycan forms in human. Among them, 96% is secreted and membrane...
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Therapeutic approaches in Congenital Disorders of Glycosylation (CDG) involving N-linked glycosylation: an update
Congenital disorders of glycosylation (CDG) are a group of clinically and genetically heterogeneous metabolic disorders. Over 150 CDG types have been...
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Suppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epithelial-mesenchymal transition and lymphatic metastasis
BackgroundAs the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour...
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N-Glycan Insertion for Probing Protein–Protein Interactions and Epitope Map**
Introducing an N-linked glycosylation motif into recombinant proteins at specific sites is a useful tool in probing protein–protein interactions and...