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Identification of Human Antigen-Specific CD4+ Cells with Peptide-MHC Multimer Technologies
Peptide-major histocompatibility complex class II (pMHCII) multimers have emerged as a convenient and powerful tool for characterization of CD4 T...
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A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and...
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Plasma oligomer beta-amyloid is associated with disease severity and cerebral amyloid deposition in Alzheimer’s disease spectrum
BackgroundMultimer detection system-oligomeric amyloid-β (MDS-OAβ) is a measure of plasma OAβ, which is associated with Alzheimer’s disease (AD)...
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Immunohistochemical Detection of p40 Expression in Lung Cancer Clinical Samples
Immunohistochemistry is the technique by which antigens in tissues are detected by means of antigen–antibody reaction. The p40 antibody is directed...
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Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system
BackgroundHomozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia...
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Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
ObjectiveWe assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we...
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The Defense Response of the Innate Immune System: Influences of Food Components on the Early Phase of the Immune Response
The complement system is a proteolytic activation cascade with diverse, antimicrobial, and immunoregulatory protein elements. It represents a key...
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Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)
BackgroundWe have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from...
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Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation
α-Synuclein (α-Syn) plays a key role in the development of Parkinson’ desease (PD). As aging is acknowledged to be the greatest risk factor for PD,...
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Identification of Human Antigen-Specific CD4+ T-Cells with Peptide–MHC Multimer Technologies
The development of peptide–MHC class II multimers has provided a novel approach in studying antigen-specific CD4+ T-cells and extended the knowledge...
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In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant, misfolded and mislocalized...
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DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
Recent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer vaccines that deliver...
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Glutamatergic System is Affected in Brain from an Hyperthermia-Induced Seizures Rat Model
AbstractOne of the most frequent neurological disorders in children is febrile seizures (FS), a risk for epilepsy in adults. Glutamate is the main...
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Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy
We performed whole-genome sequencing (WGS) in 327 children with cerebral palsy (CP) and their biological parents. We classified 37 of 327 (11.3%)...
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Automation in the Thrombosis and Hemostasis Laboratory
Automation continues to advance into hemostasis and thrombosis laboratories. Integration of hemostasis testing into an existing chemistry track...
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Anoikis resistance and immune escape mediated by Epstein-Barr virus-encoded latent membrane protein 1-induced stabilization of PGC-1α promotes invasion and metastasis of nasopharyngeal carcinoma
BackgroundEpstein-Barr virus (EBV) is the first discovered human tumor virus that is associated with a variety of malignancies of both lymphoid and...
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Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting
The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is hindered by the need to obtain large and fresh tumour...
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How location and cellular signaling combine to activate the NLRP3 inflammasome
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile...
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Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay
BackgroundMore than half of the colorectal cancer (CRC) patients will develop liver metastasis that underlies the cancer mortality. In the hepatic...
