Search
Search Results
-
Modulation of Multidrug Resistance Protein 1-mediated Transport Processes by the Antiviral Drug Ritonavir in Cultured Primary Astrocytes
The Multidrug Resistance Protein 1 (Mrp1) is an ATP-dependent efflux transporter and a major facilitator of drug resistance in mammalian cells during...
-
Different Efflux Pump Systems in Acinetobacter baumannii and Their Role in Multidrug Resistance
Several infections, such as pneumonia, urinary tract infections (UTIs), as well as bloodstream, skin, and soft tissue infections, are caused by...
-
Nano-Cargo Boarded Defensins to Combat Multidrug Resistance
Antibiotics have transformed the world of medical sciences instantaneously after their discovery. In the last few decades, the emergence of multidrug...
-
Alpha-1 antitrypsin expression is upregulated in multidrug-resistant cancer cells
Identification of the signature molecular profiles involved in therapy resistance is of vital importance in develo** new strategies for treatments...
-
Evolution and the Role of SXT-Related Integrative Conjugative Elements in Multidrug-Resistant Vibrio cholerae
The emergence of various classes of antibiotics over the years and their widespread use in clinical and food sectors resulted in antimicrobial...
-
Key genes and molecular mechanisms related to Paclitaxel Resistance
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence is...
-
Y-Box-Binding Protein-1
Various reports have proved that Y-box-binding protein-1 (YB-1) is a protein with multiple roles including transcription/translation regulation of...
-
Evolution and the Role of SXT-Related Integrative Conjugative Elements in Multidrug-Resistant Vibrio cholerae
The emergence of various classes of antibiotics over the years and their widespread use in clinical and food sectors resulted in antimicrobial...
-
Clinical manifestations, antimicrobial resistance and genomic feature analysis of multidrug-resistant Elizabethkingia strains
BackgroundElizabethkingia is emerging as an opportunistic pathogen in humans. The aim of this study was to investigate the clinical epidemiology,...
-
Role of Plant Secondary Metabolites as Modulators of Multidrug Resistance in Cancer Therapy
Cancer is one of the leading causes of global mortality and morbidity. It is caused by dysregulation of key cellular processes. Treatment of cancer...
-
Role of Gold Nanoparticles Against Multidrug Resistance (MDR) Bacteria: An Emerging Therapeutic Revolution
Multidrug resistance (MDR) due to extensive futile use of antibiotics exhibits as an emerging menace to human health toward diagnosis and treatment....
-
Intracellular Compartments and Drug Resistance
Intracellular compartments play a pivotal role in cellular function, housing diverse organelles that contribute to essential processes such as...
-
Multidrug resistance genes screening of pancreatic ductal adenocarcinoma based on sensitivity profile to chemotherapeutic drugs
BackgroundsPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types and chemotherapeutic drug resistance is a stumbling block...
-
Mechanisms of Drug Resistance in Breast Cancer
The incidence of breast cancer has increased over the past decades making it the most common cancer in females worldwide. Multidrug resistance (MDR)...
-
Y-Box-Binding Protein-1
Various reports have proved that Y-box-binding protein-1 (YB-1) is a protein with multiple roles including transcription/translation regulation of...
-
Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation
MYC upregulation is associated with multidrug refractory disease in patients with multiple myeloma (MM). We, isolated patient-derived MM cells with...
-
Metal Nanoparticles As Alternative Antimicrobial Agents to Combat Multidrug Resistance Bacteria
The rise of multidrug-resistant (MDR) bacteria poses a significant global health concern. The development of novel and effective antimicrobial agents...
-
Polymer-Based Nanomaterials Against Multidrug-Resistant Bacteria
Currently, there are major developments in the fields of medicine and biomedical engineering to mitigate the spreading of resistant bacteria and the...
-
-
Multidrug-resistant Gram-negative clinical isolates with reduced susceptibility/resistance to cefiderocol: which are the best present and future therapeutic alternatives?
PurposeTo evaluate the different present and future therapeutic β-lactam/β-lactamase inhibitor (BL/BLI) alternatives, namely aztreonam-avibactam,...