Search
Search Results
-
Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study
The mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus,...
-
A timeline of tumour-associated macrophage biology
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the...
-
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is fuelled by studies showing that ageing tissues are often...
-
Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model
Effective therapeutic strategies for triple-negative breast cancer (TNBC) are still lacking. Clinical data suggest that a large number of TNBC...
-
How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from...
-
Severely polarized extracellular acidity around tumour cells
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer...
-
Evidence for a causal role by mouse mammary tumour-like virus in human breast cancer
We have reviewed the evidence relevant to mouse mammary tumour viruses (MMTV) and human breast cancer. The prevalence of MMTV- like gene sequences is...
-
Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from...
-
Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours
BackgroundThe Oncotype DX 21-gene Recurrence Score is predictive of adjuvant chemotherapy benefit for women with early-stage, estrogen receptor...
-
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME)....
-
Unveiling Strategies to Conquer Virus-Induced Breast Cancer Drug Resistance
One of the primary causes of cancer-related deaths among women worldwide is breast cancer (BC). Conventional medical approaches to treating breast...
-
Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
BackgroundMetastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side...
-
Blocking of oestrogen signals improves anti-tumour effect regardless of oestrogen receptor alpha expression in cancer cells
BackgroundAnti-oestrogenic therapy has been used for breast cancer patients with oestrogen susceptibility cancer cells. However, little has been...
-
Involvement of redox signalling in tumour cell dormancy and metastasis
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the complexity of tumour...
-
Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
BackgroundRedox signaling caused by knockdown (KD) of Glutathione Peroxidase 2 (GPx2) in the PyMT mammary tumour model promotes metastasis via...
-
Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple tumours. However, only a few patients respond to ICIs,...
-
Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities
Although immunotherapy research to date has focused largely on T cells, there is mounting evidence that tumour-infiltrating B cells and plasma cells...
-
Oncogenic Viruses
Oncogenic viruses can produce tumours in their natural host or experimental animals or malignant transformation of the cell culture. In 1911, Rous...
-
Prevalence of MMTV-like sequences in breast cancer samples in Romanian patients-there is a geographic difference compared to the Western world
BackgroundBreast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent...
-
Catching viral breast cancer
AbstractWe have considered viruses and their contribution to breast cancer.
Mouse mammary tumour virusThe prevalence of mouse mammary tumour virus...