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Transcriptional characteristics and functional validation of three monocyte subsets during aging
BackgroundAge-associated changes in immunity are inextricably linked to chronic inflammation and age-related diseases, the impact of aging on...
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Dosimetric parameters and absolute monocyte count can predict the prognosis of acute hematologic toxicity in cervical cancer patients undergoing concurrent chemotherapy and volumetric-modulated arc therapy
PurposeTo explore clinical and dosimetric predictors of acute hematologic toxicity (HT) in cervical cancer patients treated with concurrent...
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Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection
BackgroundHIV-associated neurocognitive disorders (HAND) is hypothesized to be a result of myeloid cell-induced neuro-inflammation in the central...
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PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder
Monocyte dysfunction is critical to sepsis-induced immunosuppression. Programmed death ligand-1 (PD-L1) has shown a close relationship with...
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ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment
In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). In chronic nonresolving inflammation, mo-DCs are...
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Association of monocyte-lymphocyte ratio and proliferative diabetic retinopathy in the U.S. population with type 2 diabetes
ObjectiveDiabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early...
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A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count
BackgroundChimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and potent T-cell-mediated...
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Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility
BackgroundThe Sars-CoV-2 can cause severe pneumonia with multiorgan disease; thus, the identification of clinical and laboratory predictors of the...
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MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM...
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Use of machine learning-based integration to develop a monocyte differentiation-related signature for improving prognosis in patients with sepsis
BackgroundAlthough significant advances have been made in intensive care medicine and antibacterial treatment, sepsis is still a common disease with...
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Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation
The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However,...
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Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection
BackgroundUnderstanding the complex interactions of the immune response mediated by Mycobacterium tuberculosis and HIV co-infection is fundamental...
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Reference intervals of complete blood count parameters in the adult western Sudanese population
BackgroundA complete blood count (CBC) analysis is one of the most common conventional blood tests that physicians frequently prescribe.
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Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation
BackgroundThe involvement of the autonomic nervous system in the regulation of inflammation is an emerging concept with significant potential for...
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Predictors for CD4 cell count and hemoglobin level with survival time to default for HIV positive adults under ART treatment at University of Gondar Comprehensive and Specialized Hospital, Ethiopia
BackgroundHIV/AIDS is the most known powerful risk factor for morbidity and mortality in the world. The greatest biological markers in HIV patients...
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Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal
BackgroundMonocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age....
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Prediction of outcome using CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocyte subpopulations in patients with complicated intra-abdominal infections
There is still no study investigating the prognostic performance of CD14 ++ CD16 − , CD14 ++ CD16 + and CD14 + CD16 ++ monocyte subpopulations in complicated...
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The value of a new prognostic model developed by lymphocyte-monocyte ratio and platelet-monocyte ratio in peripheral T-cell lymphoma
Peripheral T-cell lymphoma(PTCL) is a group of lymphoproliferative tumors originated from post-thymic T cells or mature natural killer (NK) cells. It...
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Blood count changes in malaria patients according to blood groups (ABO/Rh) and sickle cell trait
IntroductionIntroduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In...
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A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis
Background'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals...
