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1. Emerging Model Organisms

   This volume discusses different approaches towards understanding the brain plasticity, aging, and regeneration of the nervous system in model...

   Wei Wang, Nicolas Rohner, Yongfu Wang in Neuromethods

   Book 2023
   

2. A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema

   Hereditary angioedema (HAE) due to C1-inhibitor deficiency is a rare, debilitating, genetic disorder characterized by recurrent, unpredictable,...

   Dan Sexton, Hoa Q. Nguyen, ... Andy Z. X. Zhu in Journal of Pharmacokinetics and Pharmacodynamics

   Article Open access 11 May 2024
   

3. Develo** a Practical Audit System for a Pharmaceutical Industry Based on Six System Inspection Model

   Six System Inspection Model is used for auditing the Pharmaceutical Organization by the United States Food & Drug Administration (USFDA). Previously...

   Aishwarya Pawar, Manohar Potdar, ... Vandana Nikam in Modern Aspects of Pharmaceutical Quality Assurance

   Chapter 2024
   

4. IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy

   Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located...

   Nicole J. Corbin-Stein, Gabrielle M. Childers, ... Ashley S. Harms in Acta Neuropathologica Communications

   Article Open access 18 January 2024
   

5. The Chick Embryo and Its Structures as a Model System for Experimental Ophthalmology

   The possibilities of using the chick embryo and its individual structures as a model system in experimental ophthalmology are considered. Cultures of...

   S. V. Kravchenko, V. V. Myasnikova, S. N. Sakhnov in Bulletin of Experimental Biology and Medicine

   Article 01 February 2023

6. Recombinant cellular model system for human muscle-type nicotinic acetylcholine receptor α1₂β1δε

   The human muscle-type nicotinic acetylcholine receptor α1 ₂ β1δε (nAChR) is a complex transmembrane receptor needed for drug screening for disorders...

   Sabrina Brockmöller, Thomas Seeger, ... Simone Rothmiller in Cell Stress and Chaperones

   Article Open access 25 November 2023
   

7. A Mouse Model of Multiple System Atrophy: Bench to Bedside

   Multiple system atrophy (MSA) is a rare neurodegenerative disorder with unclear etiology, currently difficult and delayed diagnosis, and rapid...

   Nadia Stefanova in Neurotherapeutics

   Article Open access 22 August 2022
   

8. 5-HT Neural System Abnormalities in PTSD Model Rats

   To do translational research on illness, a suitable animal model is needed. Since the symptoms of post-traumatic stress disorder (PTSD) exist across...

   Hiroki Shikanai, Hirokazu Matsuzaki, ... Takeshi Izumi in Translational Methods for PTSD Research

   Protocol 2023
   

9. SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters

   Purpose

   To construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue...

   Xavier J. H. Pepin, Iain Grant, J. Matthew Wood in Pharmaceutical Research

   Article Open access 27 August 2023
   

10. An Improved Finite Element Model of Temporomandibular Joint in Maxillofacial System: Experimental Validation

    Finite element (FE) analysis has become a popular method of exploring the biomechanical characteristics of temporomandibular joint (TMJ). However,...

    Annan Li, Desmond Y. R. Chong, ... Zhan Liu in Annals of Biomedical Engineering

    Article 23 January 2023
    

11. Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model

    Multiple system atrophy (MSA) is a rare, fatal neurodegenerative disease characterized by the accumulation of misfolded α-synuclein (αSyn) in glial...

    An Cheng, Wenbin Jia, ... Kohji Fukunaga in Acta Pharmacologica Sinica

    Article 21 August 2023
    

12. miR-122-5p Promotes Peripheral and Central Nervous System Inflammation in a Mouse Model of Intracerebral Hemorrhage via Disruption of the MLLT1/PI3K/AKT Signaling

    Intracerebral hemorrhage (ICH) is a recognized central nervous system inflammation complication. Several microRNAs (miRNAs or miRs) have been...

    Ning Yu, Wenbin Tian, ... Ya Liu in Neurochemical Research

    Article 18 August 2023
    

13. Aspirin reverts lipopolysaccharide-induced learning and memory impairment: first evidence from an invertebrate model system

    By employing a reductionistic (but not simplistic) approach using an established invertebrate model system, the pond snail Lymnaea stagnalis , we...

    Veronica Rivi, Anuradha Batabyal, ... Ken Lukowiak in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 14 September 2022
    

14. Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis

    Background

    Chronic pelvic pain (CPP) is a common symptom of endometriosis. Women with endometriosis are also at a high risk of suffering from anxiety,...

    Shah Tauseef Bashir, Catherine R. Redden, ... Romana A. Nowak in Journal of Neuroinflammation

    Article Open access 06 March 2023
    

15. A biophysical model for dopamine modulating working memory through reward system in obsessive–compulsive disorder

    Dopamine modulates working memory in the prefrontal cortex (PFC) and is crucial for obsessive–compulsive disorder (OCD). However, the mechanism is...

    Lining Yin, Fang Han, Qingyun Wang in Cognitive Neurodynamics

    Article 25 August 2023
    

16. Customizable tubular model for n-furcating blood vessels and its application to 3D reconstruction of the cerebrovascular system

    Understanding the 3D cerebral vascular network is one of the pressing issues impacting the diagnostics of various systemic disorders and is helpful...

    Michal Chlebiej, Anna Zurada, ... Maciej Szkulmowski in Medical & Biological Engineering & Computing

    Article Open access 26 January 2023
    

17. Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy

    Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by...

    Marilena Bohley, Andrea E. Dillinger, ... Achim Goepferich in Drug Delivery and Translational Research

    Article Open access 19 May 2023
    

18. Computational model of the spatiotemporal synergetic system dynamics of calcium, IP₃ and dopamine in neuron cells

    The functioning of several cellular processes in neuron cells relies on the interplay between multiple systems, such as calcium ([Ca ²⁺ ]), inositol 1,...

    Anand Pawar, Kamal Raj Pardasani in Cognitive Neurodynamics

    Article 06 May 2024
    

19. Design of a Production Planning System in a Pharmaceutical Factory: Spreadsheet Model and Case Study

    Purpose

    This work focuses on develo** a production planning tool for small- and medium-sized enterprises (SMEs) in pharmaceutical manufacturing to...

    Paweethida Niamchuen, Paveena Chaovalitwongse, Punnamee Sachakamol in Journal of Pharmaceutical Innovation

    Article 06 May 2023
    

20. Microglia-mediated drug substance transfer promotes chemoresistance in brain tumors: insights from an in vitro co-culture model using GCV/Tk prodrug system

    Background

    It is well known that tumor-associated macrophages (TAMs) play essential roles in brain tumor resistance to chemotherapy. However, the...

    Sheng-Yan Wu, Wen-Jui Yu, ... Chi-Shiun Chiang in Cancer Cell International

    Article Open access 18 January 2024