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Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors
Inhibition of enzymes responsible for endocannabinoid hydrolysis represents an invaluable emerging tool for the potential treatment of...
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Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state
BackgroundCisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and...
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Multiplex Testing of Oxidative-Reductive Pathway in Patients with COVID-19
Infection with SARS-CoV-2, the causative agent of COVID-19, causes numerous cellular dysfunctions. The virus enters the host cells and hijacks the...
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Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells
Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo...
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Mitochondrial Quality Measures in the Regulation of Tumor Progression and Metastasis
Mitochondria are positioned as a crucial cell organelle with many decisive functions. Both the lifesaving energy requirement of a cell and cell death...
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Mitochondrial Quality Measures in the Regulation of Tumor Progression and Metastasis
Mitochondria are positioned as a crucial cell organelle with many decisive functions. Both the lifesaving energy requirement of a cell and cell death...
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Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome
BackgroundRett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal...
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Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
AbstractMitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the TYMP gene, which encodes thymidine phosphorylase...
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Measurement of Mitochondrial Respiration in Cryopreserved Human Peripheral Blood Mononuclear Cells (PBMCs)
Inflammatory diseases caused by infectious agents such as the SARS-CoV-2 virus can lead to impaired reductive-oxidative (REDOX) balance and disrupted...
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Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways
The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective...
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Oleamide Reduces Mitochondrial Dysfunction and Toxicity in Rat Cortical Slices Through the Combined Action of Cannabinoid Receptors Activation and Induction of Antioxidant Activity
The potential treatment of neurodegenerative disorders requires the development of novel pharmacological strategies at the experimental level, such...
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Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue...
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Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model
Glaucoma is a neurodegenerative disease of visual system characterized by gradual loss of retinal ganglion cells (RGC). Since mitochondrial...
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SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells
Mitochondrial serine hydroxymethyltransferase (SHMT2) catalyzes the conversion of serine to glycine and concomitantly produces one-carbon units to...
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Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling
BackgroundThe mechanisms underlying metastasis of colorectal cancer (CRC) remain unclear. C14orf159 is a mitochondrial matrix protein converting d -gl...
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Glucose-conjugated glutenin nanoparticles for selective targeting and delivery of camptothecin into breast cancer cells
Receptor-mediated drug delivery systems are a promising tool for targeting malignant cells to suppress/inhibit the malignancy without disturbing...
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Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction
IntroductionSepsis-induced myocardial dysfunction (SIMD) is a condition manifested by an intrinsic myocardial systolic and diastolic dysfunction...
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A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism
BackgroundHypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a major player in clear cell renal cell carcinoma (ccRCC),...
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Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive...
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Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia
The nature of brain redox metabolism in health, aging, and disease remains to be fully established. Reversible oxidations, to disulfide bonds, of...
