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Mitochondrial Membrane Potential Assay
Mitochondrial function, a key indicator of cell health, can be assessed through monitoring changes in mitochondrial membrane potential (MMP)....
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Detection of Nanoparticle-Mediated Change in Mitochondrial Membrane Potential in T Cells Using JC-1 Dye
Alterations in mitochondrial membrane potential are associated with the generation of reactive oxygen species and cell death. While eliminating...
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Membrane potential dynamics of C5a-stimulated neutrophil granulocytes
Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to...
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Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons
Impairments in mitochondrial physiology play a role in the progression of multiple neurodegenerative conditions, including peripheral neuropathy in...
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Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells
Globally, lung cancer accounts for 18% of cancer-associated mortalities. Among the subtypes, non-small cell lung cancer (NSCLC) is the most...
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Plate-Based Assays for the Characterization of Mitochondrial and Cellular Phenotypes
The mitochondria are essential to eukaryotic life, acting as key drivers of energy generation while also being involved in the regulation of many...
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Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification
ObjectiveTo explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.
MethodsGene expression...
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Mitochondrial DNA Profiling
Mitochondrial DNA (mtDNA) is a versatile tool in understanding the clinical and non-clinical aspects attributed by the nucleotide sequences. The...
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Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by mitochondrial dysfunction and accumulation of alpha-synuclein...
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Hydrogen Sulfide Ameliorates Homocysteine-Induced Mitochondrial Autophagy Disorder in HT22 Cells
AbstractDamaged mitochondrial autophagy (mitophagy) caused by the elevated level of homocysteine (Hcy) or hyperhomocysteine (Hhcy) is closely related...
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Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
BackgroundMitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD,...
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LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells
BackgroundLeucine-rich pentatricopeptide repeat containing (LRPPRC) is a potential oncogene in multiple tumor types, including lung adenocarcinoma,...
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Development and Application of a Mitochondrial Genetically Encoded Voltage Indicator in Narcosis
Mitochondrial membrane potential (MMP) plays a crucial role in the function of cells and organelles, involving various cellular physiological...
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Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle
Connexin43 (Cx43) exits as hemichannels in the inner mitochondrial membrane. We examined how mitochondrial Cx43 and mitochondrial K ATP channels...
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Assessment of Mitochondrial Membrane Potential and NADH Redox State in Acute Brain Slices
Brain is one of the most energy-demanding organs. Energy in the form of ATP is produced in brain cells predominantly in oxidative phosphorylation...
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Mitochondrial Protein TAMM41 Modulates Depressive-like Behaviors
Several lines of evidence have highlighted the crucial role of mitochondria-based therapy in depression. However, there are still less mitochondrial...
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Mitochondrial Dysfunction and Its Role in Neurological Disorders
Mitochondria, pivotal cell organelles recognized for their paramount role in cellular energy production, play a crucial part in neurological...
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Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells
BackgroundIncreased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different...
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WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis
BackgroundDoxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore...
