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Mitochondria Modulating Therapeutic Approaches in the Management of Huntington’s Disease
Purpose of ReviewMitochondrial dysfunctions are considered epistatic to cellular malfunctions during advancement of neurodegenerative disorders,...
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Calcium signaling from sarcoplasmic reticulum and mitochondria contact sites in acute myocardial infarction
Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or...
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Focusing on mitochondria in the brain: from biology to therapeutics
Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome....
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SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs
Cardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of...
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Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in incidence and prevalence...
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Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) cascade is a pleiotropic pathway that involves...
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Glioprotective Effects of Resveratrol Against BMAA-Induced Astroglial Dysfunctions
Astroglial cells play important roles in maintaining central nervous system (CNS) homeostasis. The neurotoxin β-N-methylamino-L-alanine (BMAA) has...
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Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions
Evidence demonstrated that metabolic-associated T cell abnormalities could be detected in the early stage of RA development. In this context,...
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Mitochondria: intracellular sentinels of infections
Structure and integrity of the mitochondrial network play important roles in many cellular processes. Loss of integrity can lead to the activation of...
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Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice
AbstractAmyotrophic lateral sclerosis (ALS) may result from the dysfunctions of various mechanisms such as protein accumulation, mitophagy, and...
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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation
Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on...
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Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study
BackgroundMethamphetamine is widely abused in all parts of the world. It has been reported that short-term and long-term methamphetamine exposure...
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The Detection and Imaging of pH Values in Living Cells with Hemicyanine Based Colorimetric Mitochondria-Targeted Fluorescent Probe
pH plays a crucial role in cells, especially mitochondria, an important organelle. Develo** probes with well-performance for pH detection is still...
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Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2) in late 2019 and its spread worldwide caused an acute pandemic...
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Preparation of “Functional” Mitochondria: A Challenging Business
As the powerhouse of the cell, mitochondria, plays a crucial role in many aspects of life, whereby mitochondrial dysfunctions are associated with...
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Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis
Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce neurodegenerative disorders, such as vascular dementia. The...
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Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions
Liver steatosis, inflammation, and variable degrees of fibrosis are the pathological manifestations of nonalcoholic steatohepatitis (NASH), an...
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Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Living organisms constantly need to adapt to their surrounding environment and have evolved sophisticated mechanisms to deal with stress....
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Mitochondria as the Essence of Yang Qi in the Human Body
The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities with mitochondria in modern medicine. Both are indispensable to...
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Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Neurogenesis occurs throughout life in the hippocampus of the brain, and many environmental toxicants inhibit neural stem cell (NSC) function and...
