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Assessment of Mechanically Induced Changes in Helical Fiber Microstructure Using Diffusion Tensor Imaging
Noninvasive methods to detect microstructural changes in collagen-based fibrous tissues are necessary to differentiate healthy from damaged tissues...
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Structural Brain Correlates of Sleep Microstructure in Spinocerebellar Ataxia Type 2 and its Role on Clinical Phenotype
The influence of brain atrophy on sleep microstructure in Spinocerebellar Ataxias (SCAs) has not been extensively explored limiting the use of these...
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Microstructure predicts non-motor outcomes following deep brain stimulation in Parkinson’s disease
Deep brain stimulation of the subthalamic nucleus (STN-DBS) effectively treats motor and non-motor symptoms in advanced Parkinson’s disease (PD). As...
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Computational Analysis of the Effects of Fiber Deformation on the Microstructure and Permeability of Blood Oxygenator Bundles
Mechanical loads on the polymeric fibers of oxygenating bundles are commonly present due to bundle press-fitting during device assembly and blood...
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Evolutionary scaling and cognitive correlates of primate frontal cortex microstructure
Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding how modifications of neuron and axon distributions...
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Development of an Image-based Method for Tablet Microstructure Description and Its Correlation with API Release Rate
The performance of a pharmaceutical formulation, such as the drug (API) release rate, is significantly influenced by the properties of the materials...
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White matter microstructure of children with sensory over-responsivity is associated with affective behavior
BackgroundSensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory...
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A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs
There is an increasing demand to develop predictive medicine through the creation of predictive models and digital twins of the different body...
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Novel rivaroxaban-loaded microsphere systems with different surface microstructure for enhanced oral bioavailability
This study compares rivaroxaban-loaded polymeric microsphere systems with three types of surface microstructure. Three types of polymeric...
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Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status
BackgroundAPOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD), whereas APOE2 confers protection. However, effects of APOE ...
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Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging
PurposeClinical cone-beam computed tomography (CBCT) devices are limited to imaging features of half a millimeter in size and cannot quantify the...
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Subject classification and cross-time prediction based on functional connectivity and white matter microstructure features in a rat model of Alzheimer’s using machine learning
BackgroundThe pathological process of Alzheimer’s disease (AD) typically takes decades from onset to clinical symptoms. Early brain changes in AD...
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ADHD-related sex differences in frontal lobe white matter microstructure and associations with response control under conditions of varying cognitive load and motivational contingencies
Children with attention-deficit/hyperactivity disorder (ADHD) demonstrate reduced response inhibition, increased response time variability, and...
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Spatiotemporal Characterization of Microstructure Morphology, Mechanical Properties and Bone Remodeling of Rat Tibia Under Uniaxial Compressive Overload Loading
Bone tissue is subjected to increased mechanical stress during high-intensity work. Inadequate bone remodeling reparability can result in the...
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White matter microstructure and verbal fluency
Poor performance on verbal fluency tasks is associated with an increased risk of post-stroke cognitive impairment. Grey matter regions supporting...
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Effect of spaceflight experience on human brain structure, microstructure, and function: systematic review of neuroimaging studies
Spaceflight-induced brain changes have been commonly reported in astronauts. The role of microgravity in the alteration of the brain structure,...
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Cross-sectional and longitudinal evaluation of white matter microstructure damage and cognitive correlations by automated fibre quantification in relapsing-remitting multiple sclerosis patients
The purpose of this study was to characterize whole-brain white matter (WM) fibre tracts by automated fibre quantification (AFQ), capture subtle...
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Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism
Whether brain stimulation could modulate brain structure in autism remains unknown. This study explored the impact of continuous theta burst...
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Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development
Interest in studying neonatal development and the improved healing response observed in neonates is increasing, with the goal of using this work to...
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Evaluation of microstructure, dissolution rate, and oral bioavailability of paclitaxel poloxamer 188 solid dispersion
Poor solubility is a major challenge for enhancing the oral bioavailability and clinical application of many drugs, including the broad-spectrum...
