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Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study
MicroRNA (miRNA) has emerge as a vital regulator in the pathogenesis of intervertebral disc degeneration (IDD). However, miR-106b-5p expression in...
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Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4
AbstractFibroblast-derived exosomes have been reported to transfer microRNAs to recipient cells, where they regulate target gene expression, which is...
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Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma
BackgroundTrabecular meshwork (TM) dysfunction-induced elevation of intraocular pressure has been identified as the main risk factor of irreversible...
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Advances of Liquid Biopsy for Diagnosis of Atrial Fibrillation and Its Recurrence After Ablation in Clinical Application
Atrial fibrillation (AF) is a common arrhythmia disease with high morbidity in clinical practice and leads to stroke, heart failure, peripheral...
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Expression Profile and Relationships between microRNAs as Biomarkers in COPD Patients
AbstractChronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes airflow obstruction in the lungs. In fact, it is a...
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A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
BackgroundCurrently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein,...
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Liquid Biopsy in Coronary Heart Disease
Cardiovascular disease (CVD) remains the major cause of morbidity and mortality globally. Accumulating evidence indicates that coronary heart disease...
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Thyroid Cancer: Quantum MicroRNA Language/Artificial Intelligence (MIRAI)-Based Etiologic Analysis of Thyroid Cancer by Serum/Plasma miRNA Panel Data
We have previously demonstrated that cancer pathogenesis can be simulated in silico by using a panel of circulating microRNAs (miRNAs) as biomarkers....
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Current Insights into Signature MicroRNA Networks and Signal Transduction in Osteosarcoma
Purpose of ReviewOsteosarcoma is one of the most common types of primary bone tumors that mainly occurs in children and adolescents. It is...
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Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of...
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MicroRNAs in Blood Serum , Blood Plasma , and Cerebrospinal Fluid as Diagnostic Biomarkers of Alzheimer’s Disease
MicroRNAs (miRNAs) are a family of small, genome-encoded endogenous RNAs that are transcribed but not translated into proteins. They serve essential...
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Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia
Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the...
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ES Cells or iPS Cells, that Is the Question
There is increasing evidence that microRNA (miRNA) genes regulate cell self-renewal and pluripotency in stem cells. miR-302, miR-209, and miR-371...
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Targeting Novel microRNAs in Develo** Novel Alzheimer's Disease Treatments
Alzheimer's disease (AD) is considered a multifactorial disease and a significant cause of dementia during aging. This neurodegenerative disease...
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The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead
The attribution of seizure freedom is yet to be achieved for patients suffering from refractory epilepsy, e.g. Dravet Syndrome (DS). The confined...
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Circulating miR-133a-3p defines a low-risk subphenotype in patients with heart failure and central sleep apnea: a decision tree machine learning approach
BackgroundPatients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.
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Tumor-derived small extracellular vesicles promote breast cancer progression by upregulating PD-L1 expression in macrophages
BackgroundThe metastasis of breast cancer (BC) is a complex multi-step pathological process, strictly dependent on the intrinsic characteristics of...
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The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer’s and Parkinson’s Diseases
Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs)...
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Diagnostic, Prognostic and Theranostic Potential of miRNAs in Prostate Cancer
A novel class of gene regulators, small noncoding RNAs or microRNAs (miRNAs) has an important role in various malignancies, including prostate cancer...
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Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway
Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D...
