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Spectrofluorimetric Approach for Quantification of Cyclizine in the Presence of its Toxic Impurities in Human Plasma; in silico Study and ADMET Calculations
Cyclizine (CYZ); an antiemetic compound; is widely misused for its euphoric or hallucinatory effects, either by oral or intravenous routes. The...
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Design, synthesis and evaluation of salicylic acid-donepezil hybrids as functional agents for the treatment of Alzheimer’s disease
In this work, a series of salicylic acid derivatives was designed through the multi-target-directed ligand strategy (MTDLs). The synthesized...
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Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers
As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic...
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Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria
Cystinuria is a rare genetic disorder characterized by defective l -cystine reabsorption from the renal proximal tubule, resulting in abnormally high...
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α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives
In this study, a series of 40 semisynthetic nitrogen triterpenic derivatives of lupane, oleanane and ursane type including 33 previously synthesized...
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Imatinib@glycymicelles entrapped in hydrogel: preparation, characterization, and therapeutic effect on corneal alkali burn in mice
Imatinib (IMB) is a type of tyrosine kinase inhibitor with great application potential for inhibiting corneal neovascularization (CNV), but its poor...
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Platanic acid derived amides are more cytotoxic than their corresponding oximes
AbstractAlbeit platanic acid has been known since 1956, its potential to act as a valuable starting material for the synthesis of cytotoxic agents...
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Pharmacological evaluation of antinociceptive and anti-inflammatory activities of LQFM202: a new piperazine derivative
Advances have been made in the search for new multi-target modulators to control pain and inflammation. Therefore, compound...
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Synthesis and evaluation of new 2-oxo-1,2-dihydroquinoline-3-carboxamides as potent inhibitors against acetylcholinesterase enzyme
Alzheimer’s disease (AD), a worldwide mental disorder manifested with dementia symptoms, was used to be treated with tacrine. The latter use was...
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Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups
A novel series of silibinin and 2,3-dehydrosilybin derivatives bearing carbamate groups were designed, synthesized and their in vitro anticancer...
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Investigation of the monoamine oxidase inhibition properties of benzoxathiolone derivatives
The treatment of neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease represent significant challenges in...
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Group 14 Metallafluorenes as Sensitive Luminescent Probes of Surfactants in Aqueous Solution
Sila- and germafluorenes containing alkynyl(aryl) substituents at the 2,7- position are strongly emissive with high quantum yields in organic...
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Synthesis, characterization and anticancer evaluation of nitrogen-substituted 1-(3-aminoprop-1-ynyl)-4-hydroxyanthraquinone derivatives
Anthraquinones are of significant interest due to their biological activity, coloring properties, and synthetic applications. Here, we describe a...
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Ratiometric co-delivery of doxorubicin and paclitaxel prodrug by remote-loading liposomes for the treatment of triple-negative breast cancer
Liposomal delivery system that concurrent delivery of multiple drugs can improve efficacy of cancer treatments, yet remain challenging because of...
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Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants
The antidepressant activity of (+) and (−)-paeoveitol was first evaluated using the forced swimming test (FST), and (+)-paeoveitol showed potential...
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Rapid Analysis of Estrogens in Meat Samples by High Performance Liquid Chromatography with Fluorescence Detection
A novel reagent named 4-(N-methyl-1,3-dioxo-benzoisoquinolin-6-yl-oxy)benzene sulfonyl chloride (MBIOBS-Cl) for the determination of estrogens in...
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Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture
Excessive levels of dopamine in the synaptic cleft, induced by cocaine for example, activates dopaminergic receptors, mainly D 1 R, D 2 R, and D 3 R...
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Gastrointestinal Delivery of an mRNA Vaccine Using Immunostimulatory Polymeric Nanoparticles
mRNA vaccines can be translated into protein antigens, in vivo , to effectively induce humoral and cellular immunity against these proteins. While...
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Nanoparticles in Cancer Therapy
In the realm of cancer therapy, nanoparticles have emerged as a pioneering avenue, ushering in a remarkable journey filled with breakthroughs and...
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Clinical Aspects: Treatment of Simple and Complicated Forms of Loiasis
The filarial parasite, Loa loa, causes chronic infection in an estimated 10 million people living in Central and West Africa and in long-term...