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The extracellular matrix protein fibronectin promotes metanephric kidney development
Complex interactions of the branching ureteric bud (UB) and surrounding mesenchymal cells during metanephric kidney development determine the final...
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Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis
AbstractMesangial proliferative glomerulonephritis (MsPGN) is a glomerular disease characterized by the proliferation of mesangial cells and the...
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Connecting tubules develop from the tip of the ureteric bud in the human kidney
The connecting tubule (CNT) is a unique segment of the nephron connecting the metanephric mesenchyme (MM)-derived distal convoluted tubule (DCT) and...
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Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3...
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A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling
Mesenchymal-epithelial transition (MET) is a mechanism of endometrial epithelial regeneration. It is also implicated in adenocarcinoma and...
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Pediatric Cancers
While cancers in children and adolescents are overall rare, some cancer types occur predominantly in children and adolescents. Typical pediatric...
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Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering
Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to...
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Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters
Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor essential for the development and function of the kidney. Mutations in and deletions...
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Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes–Brocks syndrome 2
Most patients with congenital anomalies of the kidney and urinary tract (CAKUT) remain genetically unexplained. In search of novel genes associated...
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Stem Cells: Medical Marvel in Management of Kidney Diseases
Renal response to acute and chronic injury is an intricate process including a vast range of interacting molecules and is indeed a daunting task to...
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Extracellular Vesicle Biomarkers for Renal Diseases
Extracellular vesicles (EVs) are emerging as a new mechanism of intercellular communication in renal disease. EVs originating from the renal system...
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Study of cellular heterogeneity and differential dynamics of autophagy in human embryonic kidney development by single-cell RNA sequencing
BackgroundAutophagy is believed to participate in embryonic development, but whether the expression of autophagy-associated genes undergoes changes...
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Defining the variety of cell types in develo** and adult human kidneys by single-cell RNA sequencing
The kidney is among the most complex organs in terms of the variety of cell types. The cellular complexity of human kidneys is not fully unraveled...
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Experimental Tubulogenesis Induction Model in the Mouse
Kidney development and induction of tubulogenesis have been studied for almost seven decades. The experimental setup of metanephric mesenchyme...
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DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
BackgroundWhile single-cell transcriptional profiling has greatly increased our capacity to interrogate biology, accurate cell classification within...
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Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
Acute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be...
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Virus as Renal Functional Genetic Tools
Viral vectors enable efficient transfection of ectopic DNA into hard to transfect cells. Viral vectors are normally used to obtain permanent...
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The Renal Extracellular Matrix as a Supportive Scaffold for Kidney Tissue Engineering: Progress and Future Considerations
During the past decades, diverse methods have been used toward renal tissue engineering in order to replace renal function. The goals of all these...
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Wnt signaling in kidney: the initiator or terminator?
The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease...
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Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers
In order to harness the potential of pluripotent stem cells, we need to understand how to differentiate them to our target cell types. Here, we...
