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Pancancer network analysis reveals key master regulators for cancer invasiveness
BackgroundTumor invasiveness reflects numerous biological changes, including tumorigenesis, progression, and metastasis. To decipher the role of...
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The glucocorticoid receptor as a master regulator of the MĂĽller cell response to diabetic conditions in mice
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. MĂĽller glia cells are at the centre of the retinal...
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Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
BackgroundObesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot...
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Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis
Arsenic is a pervasive environmental toxin that is listed as the top priority for investigation by the Agency for Toxic Substance and Disease...
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Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)
Oxytosis/ferroptosis is an iron-dependent oxidative form of cell death triggered by lethal accumulation of phospholipid hydroperoxides (PLOOHs) in...
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Identification of RIOK2 as a master regulator of human blood cell development
Anemia is a major comorbidity in aging, chronic kidney and inflammatory diseases, and hematologic malignancies. However, the transcriptomic networks...
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Liprin-α proteins are master regulators of human presynapse assembly
The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell–cell...
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Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in the majority of brain tumors, including adult...
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Pragmatic nationwide master observational trial based on genomic alterations in advanced solid tumors: KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS)-II study protocol KCSG AL-22–09
BackgroundNext-generation sequencing (NGS) has been introduced to many Korean institutions to support molecular diagnostics in cancer since 2017,...
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Tumor Suppressor Genes and Cell Fate Control
In this chapter, we will present the transcription factor p53, which is encoded by the most prominent cancer driver gene, the tumor suppressor gene...
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Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis
Elderly patients infected with severe acute respiratory syndrome coronavirus 2 are at higher risk of severe clinical manifestation, extended...
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Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within...
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Imprinted genes and the manipulation of parenting in mammals
Genomic imprinting refers to the parent-of-origin expression of genes, which originates from epigenetic events in the mammalian germ line. The...
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DNA: The Master Molecule
All living creatures have DNA (deoxyribonucleic acid) as their blueprint for life. This DNA primarily exists in the famous double helix and is...
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Delineation and authentication of ferroptosis genes in ventilator-induced lung injury
BackgroundMechanical ventilation, a critical support strategy for individuals enduring severe respiratory failure and general anesthesia,...
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Identification of Potential Neddylation-related Key Genes in Ischemic Stroke based on Machine Learning Methods
Ischemic stroke (IS) is a complex neurological disease that can lead to severe disability or even death. Understanding the molecular mechanisms...
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High-throughput analysis of the transcriptional patterns of sexual genes in malaria
BackgroundPlasmodium falciparum ( Pf ) is the leading protozoan causing malaria, the most devastating parasitic disease. To ensure transmission, a...
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Conditional transcriptome-wide association study for fine-map** candidate causal genes
Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association studies with expression-map** studies to identify genes...
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Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease
BackgroundOwing to the heterogeneity of Alzheimer's disease (AD), its pathogenic mechanisms are yet to be fully elucidated. Evidence suggests an...
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Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Liver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes...
