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Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model
Oxidative stress (OS) is the main cause of secondary damage following intracerebral hemorrhage (ICH). The polarity expression of aquaporin-4 (AQP4)...
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miR-211-5p targeting MMP9 regulates the expressions of AQP4 in traumatic brain injury
ObjectiveThe abnormal expression of matrix metalloproteinase 9 (MMP9) and Aquaporin 4 (AQP4) closely associates with the traumatic brain injury (TBI)...
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Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action
Hepatocellular carcinoma (HCC) is a serious and potentially fatal form of cancer associated with liver damage. New anticancer drugs are increasingly...
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Cysteine protease inhibitor S promotes lymph node metastasis of esophageal cancer cells via VEGF-MAPK/ERK-MMP9/2 pathway
Cysteine protease inhibitor S (CST4) plays a pivotal role in the regulation of growth, invasion, and metastasis of a variety of malignancies....
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Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis
BackgroundHepatocellular carcinoma (HCC) cell-derived exosomal LncRNA SNHG16 is highly expressed and associated with poor overall survival of...
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Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
BackgroundPostoperative pain is a serious clinical problem with a poorly understood mechanism, and lacks effective treatment. Hydrogen (H 2 ) can...
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Tumor-matched and unmatched cancer associated fibroblasts exhibit differential effect on proliferation and FMOD and MMP9 gene expression in head and neck squamous cell carcinoma cells when cocultured in spheroids
BackgroundCancer-associated fibroblasts (CAFs) are the major cellular component of the tumor microenvironment and are known to affect tumor growth...
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Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study
We previously identified matrix metalloproteinase 2 (MMP2) and MMP9 plasma levels as candidate biomarkers of bevacizumab activity in patients with...
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Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis
Besides cell death, caspase-9 participates in non-apoptotic events, including cell differentiation. To evaluate a possible impact on the expression...
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MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
BackgroundMatrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9...
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Investigating the Effect of Silica Nanoparticles on MMP9, HAS2, ITGAX, and Additional Key Genes: Implications for Enhanced Wound Healing
AbstractNanoparticles are an essential aspect of current scientific evolution, offering several potential applications in a number of fields....
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MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma
BackgroundUveal melanoma (UVM) is the leading cause of eye-related mortality worldwide. This study aimed to explore the expression and prognostic...
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Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture
BackgroundDespite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. Xanthohumol (XN)...
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9
ObjectivesThis study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with...
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Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis
BackgroundBreast cancer (BC) is a leading cause of cancer-related death in females worldwide. Previous studies have demonstrated that matrix...
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TIMELESS inhibits breast cancer cell invasion and metastasis by down-regulating the expression of MMP9
Breast cancer is the first killer leading to female death, and tumor metastasis is one of the important factors leading to the death of patients, but...
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Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness
BackgroundAngiopoietin-like protein 1 (ANGPTL1) has been proved to suppress tumor metastasis in several cancers. However, its extracellular effects...
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Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
PurposeTargeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma...
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MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway
BackgroundMicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored...
