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Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
BackgroundColorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effective therapies....
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Integrating genomics and proteomics data to identify candidate plasma biomarkers for lung cancer risk among European descendants
BackgroundPlasma proteins are potential biomarkers for complex diseases. We aimed to identify plasma protein biomarkers for lung cancer.
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A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m 6 A) modifications. A better understanding of the...
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Antibacterial, antibiofilm, and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against multidrug‐resistant bacteria
To evaluate the antibacterial, antibiofilm and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against...
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Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome
BackgroundChronic kidney disease (CKD) is a progressive disease for which there is no effective cure. We aimed to identify potential drug targets for...
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RNA modification-related variants in genomic loci associated with body mass index
BackgroundGenome-wide association studies (GWASs) have identified hundreds of loci for body mass index (BMI), but functional variants in these loci...
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Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
BackgroundHydrogen sulfide (H 2 S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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Systemic Oncosphere: Host Innate Immune System
Immune system has been known as the “predator” of cancer cells. Their original function is the prey upon non-self-cells, including during infections...
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Roles of cytotoxic lymphocytes and MIC/LILR families in pathophysiology of Takayasu arteritis
Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe...
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A novel approach for relapsed/refractory FLT3mut+ acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib
BackgroundPatients with relapsed/refractory acute myeloid leukaemia (AML) with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have...
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Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
BackgroundPatients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose...
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The emerging role of glycolysis and immune evasion in gastric cancer
Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Similar to other types of...
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Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Despite good results in the treatment of hematological malignancies, Natural killer (NK) cells have shown limited effectiveness in solid tumors, such...
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Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Great strides have been made in recent years towards understanding the roles of natural killer (NK) cells in immunity to tumours and viruses. NK...
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HLA Genetics for the Human Diseases
Highly polymorphic human leukocyte antigen (HLA) molecules (alleles) expressed by different classical HLA class I and class II genes have crucial...
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Role of NK Cells in Tumor Progression
Natural Killer (NK) cells are effector lymphocytes with the ability to generate an antitumor response. NK cells encompass a diverse group of subsets...
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Modulation of MHC and MHC-Like Molecules by Varicella Zoster Virus
Varicella zoster virus (VZV) is a medically important human herpesvirus that has co-evolved with the human host to become a highly successful and...
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Antigen-Presenting Cells and MHCs
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...