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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
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Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis
PurposeMajor histocompatibility complex (MHC) class II deficiency is one of the combined immune deficiency disorders caused by defects in the MHC...
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MHC II immunogenicity shapes the neoepitope landscape in human tumors
Despite advances in predicting physical peptide-major histocompatibility complex I (pMHC I) binding, it remains challenging to identify functionally...
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Antiallergic Effects of Technologically Processed Antibodies to MHC II
The risk of develo** anaphylactic reactions to medications introduces additional difficulties for effective pharmacotherapy. Using a model of...
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Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland
In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary significance is less clear. Genes...
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Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish
Duplicates of genes for major histocompatibility complex (MHC) molecules can be subjected to selection independently and vary markedly in their...
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Distinct evolutionary trajectories of MHC class I and class II genes in Old World finches and buntings
Major histocompatibility complex (MHC) genes code for key proteins of the adaptive immune system, which present antigens from intra-cellular (MHC...
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How to Predict Binding Specificity and Ligands for New MHC-II Alleles with MixMHC2pred
MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind to their ligands with high specificity. The very high...
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Dog leukocyte antigen genoty** across class I and class II genes in beagle dogs as laboratory animals
Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity...
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Characterization and genetic diversity of MHC class II DRB genes in the Arabian camel (Camelus dromedarius)
This study investigated the MHC DRB genes in the Arabian camel ( Camelus dromedarius ). The results revealed the presence of — at least — two...
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Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic...
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Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
CD4 + T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8 + T lymphocytes. In...
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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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Clinical, Immunological, and Genetic Findings in Iranian Patients with MHC-II Deficiency: Confirmation of c.162delG RFXANK Founder Mutation in the Iranian Population
PurposeMajor histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immunity (IEI). Impaired antigen presentation to...
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Identification of Human Antigen-Specific T Cells Using Class II MHC Tetramer Staining and Enrichment
The development of peptide–major histocompatibility complex tetramers has enabled direct characterization and enumeration of antigen-specific T...
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MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8
BackgroundThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes non-symptomatic infection, mild influenza-like symptoms to...
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MHCtools 1.5: Analysis of MHC Sequencing Data in R
The genes of the major histocompatibility complex (MHC) play a vital role in the vertebrate immune system and have attracted considerable interest in...
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The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurations
African buffalo ( Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of...
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MHC class II in renal tubules plays an essential role in renal fibrosis
Immunomodulation is considered a potential therapeutic approach for chronic kidney disease (CKD). Although it has been previously reported that CD4 + ...
