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Disseminated coccidioidomycosis in immunocompetent patients in non-endemic areas: a case series and literature review
Coccidioidomycosis is caused by the dimorphic fungi Coccidioides species which is endemic in the Western hemisphere. Reports on the characteristics...
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Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway
Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies worldwide and is associated with high morbidity and mortality....
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Lupus progression deteriorates oogenesis quality in MRL/lpr mice
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous...
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Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3
PurposeGermline loss-of-function variants in the signal transducer and activator of transcription 3 ( STAT3 ) gene result in autosomal dominant hyper...
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Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma
BackgroundSquamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma skin cancer. Monocyte chemotactic protein 1-induced protein 1...
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Novel NCF2 Mutation Causing Chronic Granulomatous Disease
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder caused by defects in the NADPH oxidase complex. Mutations in NCF2 ...
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First molecular evidence of bovine hemoplasma species (Mycoplasma spp.) in water buffalo and dairy cattle herds in Cuba
BackgroundHemotropic mycoplasmas (aka hemoplasmas) are small bacteria which cause infectious anemia in several mammalian species including humans....
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C1r/C1s deficiency is insufficient to induce murine systemic lupus erythematosus
C1s deficiency is strongly associated with the development of human systemic lupus erythematosus (SLE); however, the mechanisms by which C1s ...
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Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity
Gain-of-function mutations in the gene encoding the phosphatidylinositol-3-OH kinase catalytic subunit p110δ (PI3Kδ) result in a human primary...
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Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection
Approximately 2 billion people are infected with Mycobacterium tuberculosis ( Mtb ), resulting in 1.4 million deaths every year. Among Mtb -infected...
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Viruses with Single-Stranded RNA Genomes and Double-Stranded DNA as an Intermediate Product
Retroviruses were described for the first time about 100 years ago: in 1908, Vilhelm Ellermann and Oluf Bang demonstrated the transmission of avian...
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An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity
BackgroundLassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa...
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Microbe-Induced Epigenetic Alterations
In addition to the DNA and RNA tumor viruses affecting the epigenotype of their host cells (see 8), certain viruses which are not directly involved...
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Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)
BackgroundWe have previously reported a novel constitutively overexpressed 21 kDa protein in Hodgkin Lymphoma (HL) and aggressive Non-Hodgkin...
