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Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone
PurposeLung fibrosis is a heterogeneous lung condition characterized by excessive accumulation of scarred tissue, leading to lung architecture...
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Lung nodule malignancy classification with associated pulmonary fibrosis using 3D attention-gated convolutional network with CT scans
BackgroundChest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While pulmonary fibrosis indicates increased lung...
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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling and the excessive accumulation of extracellular matrix (ECM)...
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Incomplete Knockdown of MyD88 Inhibits LPS-Induced Lung Injury and Lung Fibrosis in a Mouse Model
Acute lung injury (ALI) is a life-threatening disorder stemmed mainly from an uncontrolled inflammatory response. Lipopolysaccharide (LPS) is...
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ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice
BackgroundAcute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary...
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UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis
The aging lungs are vulnerable to chronic pulmonary diseases; however, the underlying mechanisms are not well understood. In this study, we compared...
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Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway
Background and purposeInterstitial lung disease (ILD) represents a significant complication of rheumatoid arthritis (RA) that lacks effective...
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Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis
PurposeWe aimed to evaluate whether pulmonary fibrosis occurs in type 2 diabetes rat models and whether VD3 can prevent it by inhibiting pyroptosis.
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Carvacrol protects rats against bleomycin-induced lung oxidative stress, inflammation, and fibrosis
The main objective of this study was to investigate the potential efficacy of carvacrol (CAR) in mitigating bleomycin (BLM)-induced pulmonary...
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Macrolides and Interstitial Lung Diseases
Macrolide antibiotics are well known for their antibacterial properties, but extensive research in inflammatory lung diseases such as diffuse...
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Idiopathic Pulmonary Fibrosis
The unknown aetiology of irreversible fibrotic scarring of lung tissues in Idiopathic Pulmonary Fibrosis (IPF) has resulted in the lack of a gold...
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Mesenchymal stem cells suppressed skin and lung inflammation and fibrosis in topoisomerase I-induced systemic sclerosis associated with lung disease mouse model
Systemic sclerosis associated with lung interstitial lung disease (SSc-ILD) is the most common cause of death among patients with SSc. Mesenchymal...
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Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis
IntroductionThis study investigates the interactions between histaminergic system and glucocorticoid-induced leucin zipper (GILZ) in the inflammatory...
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From COVID to fibrosis: lessons from single-cell analyses of the human lung
The increased resolution of single-cell RNA-sequencing technologies has led to major breakthroughs and improved our understanding of the normal and...
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Characterisation of changes in global genes expression in the lung of ICR mice in response to the inflammation and fibrosis induced by polystyrene nanoplastics inhalation
This study characterised the changes in global gene expression in the lung of ICR mice in response to the inflammation and fibrosis induced by the...
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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosis
Treatment of the common life-limiting genetic disease cystic fibrosis (CF) has been transformed by small molecule therapeutics that target the root...
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Explicate molecular landscape of combined pulmonary fibrosis and emphysema through explainable artificial intelligence: a comprehensive analysis of ILD and COPD interactions using RNA from whole lung homogenates
Combined pulmonary fibrosis and emphysema (CPFE) presents a unique challenge in respiratory disorders, merging features of interstitial lung disease...
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Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT
PurposeEvaluate the behavior of lung nodules occurring in areas of pulmonary fibrosis and compare them to pulmonary nodules occurring in the...
